C-C Chemokine Receptor Type 5 (CCR5) Rat Recombinant Protein

CCR5: a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1). Variations in CCR5 gene also influence the rate of progression to AIDS after infection. R60S variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors. Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, cytokine; GPCR, family 1; Motility/polarity/chemotaxis; Receptor, GPCR

Cellular Component: cell surface; cytoplasm; plasma membrane; integral to membrane; endosome; external side of plasma membrane

Molecular Function: protein binding; C-C chemokine receptor activity; C-C chemokine binding; glycoprotein binding; actin binding; protein kinase binding

Biological Process: fat cell differentiation; response to lipopolysaccharide; defense response; negative regulation of axon extension; positive regulation of interleukin-1 beta secretion; chemotaxis; positive regulation of apoptosis by virus; elevation of cytosolic calcium ion concentration; cell-cell signaling; calcium ion transport; forebrain development; positive regulation of cell-cell adhesion; inflammatory response; negative regulation of cell migration; aging; calcium-mediated signaling; MAPKKK cascade; positive regulation of interleukin-6 production; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; positive regulation of tumor necrosis factor production; G-protein coupled receptor protein signaling pathway; inflammatory response to antigenic stimulus; defense response to bacterium; positive regulation of fever; response to ionizing radiation; positive regulation of neuron differentiation; leukocyte migration; positive regulation of inflammatory response