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PHD Finger Protein 1 (PHF1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1240303

This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks,… More details

$1365 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PHD finger protein 1 (PHF1), Recombinant Protein
Full Product Name
Recombinant Human PHD finger protein 1 (PHF1)
Product Gene Name
PHF1 recombinant protein
Sequence
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE RSSRLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTS FPSGQGPGGG VSRPLGKRRR PEPEPLRRRQ KGKVEELGPP SAVRNQPEPQ EQRERAHLQR ALQASVSPPS PSPNQSYQGS SGYNFRPTDA RCLPSSPIRM FASFHPSAST AGTSGDSGPP DRSPLELHIG FPTDIPKSAP HSMTASSSSV SSPSPGLPRR SAPPSPLCRS LSPGTGGGVR GGVGYLSRGD PVRVLARRVR PDGSVQYLVE WGGGGIF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
49,643 Da
Sequence Positions
1-567, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
602881
3D Structure
ModBase 3D Structure for O43189
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PHF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHF1 purchase

MBS1240303 is a recombinant protein targeting PHF1. Also known as Recombinant Human PHD finger protein 1 (PHF1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for PHF1. It may not necessarily be applicable to this product.

NCBI GI #
4505777
NCBI GeneID
5252
NCBI Accession #
NP_002627.1
UniProt Primary Accession #
O43189
UniProt Secondary Accession #
O60929; Q5SU07; Q5SU08; Q96KM7; B1AZX2; B1AZX3
UniProt Related Accession #
O43189
GenBank Nucleotide #
NM_002636.4
NCBI Official Full Name
PHD finger protein 1 isoform a
NCBI Official Synonym Full Names
PHD finger protein 1
NCBI Official Symbol
PHF1
NCBI Official Synonym Symbols
PCL1; PHF2; hPHF1; MTF2L2; TDRD19C
UniProt Protein Name
PHD finger protein 1
UniProt Synonym Protein Names
Polycomb-like protein 1; hPCl1
Protein Family
PHD finger protein
UniProt Gene Name
PHF1
UniProt Synonym Gene Names
PCL1; Protein PHF1; hPHF1; hPCl1
NCBI Protein Information
PHD finger protein 1

UniProt Comments for PHF1

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
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Research Articles on PHF1

1. the increase of DNA accessibility within the H3K36me3-containing nucleosome, instigated by the Tudor domain of PHF1 binding to H3K36me3, is dramatically enhanced by the PHF1 N-terminal domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PHF1 recombinant protein

 Reference Product  PubMed Publications
 EZH2 recombinant protein  >6 publications with PHF1 and EZH2

Pathways associated with PHF1 recombinant protein

 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 PRC2 Methylates Histones And DNA Pathway antibodies  PRC2 Methylates Histones And DNA Pathway Diagram

Diseases associated with PHF1 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >31 publications with PHF1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >9 publications with PHF1 and Disease Models, Animal
 Learning Disorders Antibodies  >3 publications with PHF1 and Learning Disorders
 Congenital Abnormalities Antibodies  >2 publications with PHF1 and Congenital Abnormalities
 Movement Disorders Antibodies  >2 publications with PHF1 and Movement Disorders
 Breast Neoplasms Antibodies  >1 publications with PHF1 and Breast Neoplasms
 Fatigue Antibodies  >1 publications with PHF1 and Fatigue
 Inflammation Antibodies  >1 publications with PHF1 and Inflammation
 Necrosis Antibodies  >1 publications with PHF1 and Necrosis

Organs/Tissues associated with PHF1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >35 publications with PHF1 and Brain
 Nerve Antibodies  >6 publications with PHF1 and Nerve
 Muscle Antibodies  >2 publications with PHF1 and Muscle
 Eye Antibodies  >2 publications with PHF1 and Eye
 Bone Antibodies  >2 publications with PHF1 and Bone
 Blood Antibodies  >1 publications with PHF1 and Blood
 Kidney Antibodies  >1 publications with PHF1 and Kidney
 Ovary Antibodies  >1 publications with PHF1 and Ovary
 Embryonic Tissue Antibodies  >1 publications with PHF1 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with PHF1 and Pancreas
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