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GPI Ethanolamine Phosphate Transferase 1 (PIGN) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1241536

MBS1241536 is a recombinant protein targeting PIGN. Also known as Recombinant Human GPI ethanolamine phosphate transferase 1 (PIGN) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1895 / 1 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GPI ethanolamine phosphate transferase 1 (PIGN), Recombinant Protein
Full Product Name
Recombinant Human GPI ethanolamine phosphate transferase 1 (PIGN) , partial
Product Gene Name
PIGN recombinant protein
Sequence
MLLFFTLGLL IHFVFFASIF DIYFTSPLVH GMTPQFTPLP PPARRLVLFV ADGLRADALY ELDENGNSRA PFIRNIIMHE GSWGISHTRV PTESRPGHVA LIAGFYEDVS AVAKGWKENP VEFDSLFNES KYTWSWGSPD ILPMFAKGAS GDHVYTYSYD AKREDFGAQD ATKLDTWVFD NVKDFFHHAR NNQSLFSKIN EEKIVFFLHL LGIDTNGHAH RPSSRDYKHN IKKVDDGVKE IVSMFNHFYG NDGKTTFIFT SDHGMTDWGS HGAGHPSETL TPLVTWGAGI KYPQRVSAQQ FDDAFLKEWR LENWKRLDVN QADIAPLMTS LIGVPFPLNS VGILPVDYLN NTDLFKAESM FTNAVQILEQ FKVKMTQKKE VTLPFLFTPF KLLSDSKQFN ILRKARSYIK HRKFDEVVSL CKELIHLALK GLSYYHTYDR FFLGVNVVIG FVGWISYASL LIIKSHSNLI KGVSKEVKKP SHLLPCSFVA IGILVAFFLL IQACPWTYYV YGLLPLPIWY AVLREFQVIQ DLVVSVLTYP LSHFVGYLLA FTLGIEVLVL SFFYRYMLTA GLTAFAAWPF LTRLWTRAKM TSLSWTFFSL LLAVFPLMPV VGRKPDISLV MGAGLLVLLL SLCVVTSLMK RKDSFIKEEL LVHLLQVLST VLSMYVVYST QSSLLRKQGL PLMNQIISWA TLASSLVVPL LSSPVLFQRL FSILLSLMST YLLLSTGYEA LFPLVLSCLM FVWINIEQET LQQSGVCCKQ KLTSIQFSYN TDITQFRQLY LDDIRRAFFL VFFLVTAFFG TGNIASINSF DLASVYCFLT VFSPFMMGAL MMWKILIPFV LVMCAFEAVQ LTTQLSSKSL FLIVLVISDI MALHFFFLVK DYGSWLDIGT SISHYVIVMS MTIFLVFLNG LAQLLTTKKL RLCGKPKSHF M
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
105,810 Da
Sequence Positions
1-931
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
606097
3D Structure
ModBase 3D Structure for O95427
Species
Homo sapiens (Human)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PIGN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PIGN. It may not necessarily be applicable to this product.

NCBI GI #
6912500
NCBI GeneID
23556
NCBI Accession #
NP_036459.1
UniProt Primary Accession #
O95427
UniProt Secondary Accession #
Q7L8F8; Q8TC01; Q9NT05
UniProt Related Accession #
O95427
GenBank Nucleotide #
NM_012327.5
NCBI Official Full Name
GPI ethanolamine phosphate transferase 1
NCBI Official Synonym Full Names
phosphatidylinositol glycan anchor biosynthesis class N
NCBI Official Symbol
PIGN
NCBI Official Synonym Symbols
MCD4; MDC4; MCAHS; PIG-N; MCAHS1
UniProt Protein Name
GPI ethanolamine phosphate transferase 1
UniProt Synonym Protein Names
MCD4 homolog; Phosphatidylinositol-glycan biosynthesis class N protein; PIG-N
UniProt Gene Name
PIGN
UniProt Synonym Gene Names
MCD4; PIG-N
NCBI Protein Information
GPI ethanolamine phosphate transferase 1

NCBI Summary for PIGN

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is expressed in the endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor. Two alternatively spliced variants, which encode an identical isoform, have been reported. [provided by RefSeq, Jul 2008]
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UniProt Comments for PIGN

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (). May act as suppressor of replication stress and chromosome missegregation.
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Research Articles on PIGN

1. PIGN is a novel biomarker of CIN and leukemic transformation/progression in a subgroup of patients with MDS or AML-MRC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PIGN recombinant protein

 Reference Product  PubMed Publications
 PIGM recombinant protein  >3 publications with PIGN and PIGM
 PIGO recombinant protein  >2 publications with PIGN and PIGO
 PIGV recombinant protein  >2 publications with PIGN and PIGV
 PIGB recombinant protein  >1 publications with PIGN and PIGB
 TNFRSF11A recombinant protein  >1 publications with PIGN and TNFRSF11A

Pathways associated with PIGN recombinant protein

 Products by Pathway  Pathway Diagram
 GPI-anchor Biosynthesis, Core Oligosaccharide Pathway antibodies  GPI-anchor Biosynthesis, Core Oligosaccharide Pathway Diagram
 GPI-anchor Biosynthesis, Core Oligosaccharide Pathway antibodies  GPI-anchor Biosynthesis, Core Oligosaccharide Pathway Diagram
 Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies  Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram
 Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies  Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies  Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Synthesis Of Glycosylphosphatidylinositol (GPI) Pathway antibodies  Synthesis Of Glycosylphosphatidylinositol (GPI) Pathway Diagram

Diseases associated with PIGN recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >23 publications with PIGN and Kidney Diseases
 Hypertension Antibodies  >4 publications with PIGN and Hypertension
 Cardiovascular Diseases Antibodies  >4 publications with PIGN and Cardiovascular Diseases
 Edema Antibodies  >3 publications with PIGN and Edema
 Musculoskeletal Diseases Antibodies  >3 publications with PIGN and Musculoskeletal Diseases
 Vascular Diseases Antibodies  >3 publications with PIGN and Vascular Diseases
 Hemorrhage Antibodies  >2 publications with PIGN and Hemorrhage
 Pneumonia Antibodies  >2 publications with PIGN and Pneumonia
 Atrophy Antibodies  >2 publications with PIGN and Atrophy
 Inflammation Antibodies  >2 publications with PIGN and Inflammation

Organs/Tissues associated with PIGN recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with PIGN and Blood
 Vascular Antibodies  >4 publications with PIGN and Vascular
 Ovary Antibodies  >2 publications with PIGN and Ovary
 Pancreas Antibodies  >1 publications with PIGN and Pancreas
 Skin Antibodies  >1 publications with PIGN and Skin
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