Human KATNA1 Recombinant Protein – Cat# MBS1246799

Katanin P60 Atpase-Containing Subunit A1 (KATNA1) Human Recombinant Protein

Name: KATNA1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1246799
Price: 1290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1246799

$1290 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Katanin p60 ATPase-containing subunit A1 (KATNA1), Recombinant Protein

Full Product Name

Recombinant Human Katanin p60 ATPase-containing subunit A1 (KATNA1)

Product Gene Name

KATNA1 recombinant protein

Sequence

MSLLMISENV KLAREYALLG NYDSAMVYYQ GVLDQMNKYL YSVKDTYLQQ KWQQVWQEIN VEAKHVKDIM KTLESFKLDS TPLKAAQHDL PASEGEVWSM PVPVERRPSP GPRKRQSSQY SDPKSHGNRP STTVRVHRSS AQNVHNDRGK AVRCREKKEQ NKGREEKNKS PAAVTEPETN KFDSTGYDKD LVEALERDII SQNPNVRWDD IADLVEAKKL LKEAVVLPMW MPEFFKGIRR PWKGVLMVGP PGTGKTLLAK AVATECKTTF FNVSSSTLTS KYRGESEKLV RLLFEMARFY SPATIFIDEI DSICSRRGTS EEHEASRRVK AELLVQMDGV GGTSENDDPS KMVMVLAATN FPWDIDEALR RRLEKRIYIP LPSAKGREEL LRISLRELEL ADDVDLASIA ENMEGYSGAD ITNVCRDASL MAMRRRIEGL TPEEIRNLSK EEMHMPTTME DFEMALKKVS KSVSAADIER YEKWIFEFGS C

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

35,319 Da

Sequence Positions

1-491aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

606696

3D Structure

ModBase 3D Structure for O75449

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KATNA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KATNA1 purchase

MBS1246799 is a recombinant protein targeting KATNA1. Also known as Recombinant Human Katanin p60 ATPase-containing subunit A1 (KATNA1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for KATNA1. It may not necessarily be applicable to this product.

NCBI GI #

323276651

NCBI GeneID

11104

NCBI Accession #

NP_001191005.1

UniProt Primary Accession #

O75449

UniProt Secondary Accession #

Q5TFA8; Q5TFA9; Q86VN2; Q9NU52; E1P5A3

UniProt Related Accession #

O75449

GenBank Nucleotide #

NM_001204076.1

NCBI Official Full Name

katanin p60 ATPase-containing subunit A1 isoform 2

NCBI Official Synonym Full Names

katanin catalytic subunit A1

NCBI Official Symbol

KATNA1

UniProt Protein Name

Katanin p60 ATPase-containing subunit A1

UniProt Synonym Protein Names

p60 katanin

UniProt Gene Name

KATNA1

UniProt Synonym Gene Names

Katanin p60 subunit A1

NCBI Protein Information

katanin p60 ATPase-containing subunit A1

NCBI Summary for KATNA1

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

UniProt Comments for KATNA1

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Research Articles on KATNA1

1. CAMSAP3 precisely coordinates with dynein and katanin to regulate the microtubule detachment process.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KATNA1 recombinant protein

Reference Product	PubMed Publications
KATNB1 recombinant protein	>2 publications with KATNA1 and KATNB1

Pathways associated with KATNA1 recombinant protein

Products by Pathway	Pathway Diagram
Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies	Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram

Organs/Tissues associated with KATNA1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with KATNA1 and Brain