Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5 (LGR5) Human Recombinant Protein

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a st cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal st cells during postembryonic development.

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Small volumes of LGR5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1247111 is a recombinant protein targeting LGR5. Also known as Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.