Mouse SDCBP Recombinant Protein – Cat# MBS1248108

Syntenin-1 (SDCBP) Mouse Recombinant Protein

Name: SDCBP Recombinant Protein; Syntenin-1; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1248108
Price: 990 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1248108

This protein was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This… More details

$990 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Syntenin-1 (Sdcbp), Recombinant Protein

Full Product Name

Recombinant Mouse Syntenin-1 (Sdcbp)

Product Gene Name

Sdcbp recombinant protein

Sequence

SLYPSLEDLK VDKVIQAQTA YSANPASQAF VLVDASAALP PDGNLYPKLY PELSQYMGLS LNEAEICESM PMVSGAPAQG QLVARPSSVN YMVAPVTGND AGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTVT MHKDSSGHVG FIFKSGKITS IVKDSSAARN GLLTDHHICE INGQNVIGLK DAQIADILST AGTVVTITIM PTFIFEHIIK RMAPSIMKSL MDHTIPEV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

32,379 Da

Sequence Positions

2-299aa; Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for O08992

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Sdcbp recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sdcbp purchase

MBS1248108 is a recombinant protein targeting Sdcbp. Also known as Recombinant Mouse Syntenin-1 (Sdcbp). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Sdcbp. It may not necessarily be applicable to this product.

NCBI GI #

148277640

NCBI GeneID

53378

NCBI Accession #

NP_001091697.1

UniProt Primary Accession #

O08992

UniProt Secondary Accession #

Q544P5; A2AKJ7

UniProt Related Accession #

O08992

GenBank Nucleotide #

NM_001098227.1

NCBI Official Full Name

syntenin-1 isoform 1

NCBI Official Synonym Full Names

syndecan binding protein

NCBI Official Symbol

Sdcbp

NCBI Official Synonym Symbols

Sycl; MDA-9; syntenin-1

UniProt Protein Name

Syntenin-1

UniProt Synonym Protein Names

Scaffold protein Pbp1; Syndecan-binding protein 1

Protein Family

Syntenin

UniProt Gene Name

Sdcbp

NCBI Protein Information

syntenin-1

UniProt Comments for Sdcbp

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway ().

Research Articles on Sdcbp

1. Present study is the first demonstration of the relevance of MDA-9/Syntenin expression in regulating inflammation and immunosuppression in the microenvironment thereby impacting tumor growth and metastasis in mouse melanoma model.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Sdcbp recombinant protein

Reference Product	PubMed Publications
Sdc2 recombinant protein	>4 publications with Sdcbp and Sdc2
Il5ra recombinant protein	>3 publications with Sdcbp and Il5ra
Cd63 recombinant protein	>3 publications with Sdcbp and Cd63
Sdc4 recombinant protein	>2 publications with Sdcbp and Sdc4
Ulk1 recombinant protein	>2 publications with Sdcbp and Ulk1
Trp53 recombinant protein	>1 publications with Sdcbp and Trp53
Nfasc recombinant protein	>1 publications with Sdcbp and Nfasc

Pathways associated with Sdcbp recombinant protein

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Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
EPH-Ephrin Signaling Pathway antibodies	EPH-Ephrin Signaling Pathway Diagram
Ephrin Signaling Pathway antibodies	Ephrin Signaling Pathway Diagram
IL-5 Signaling Pathway antibodies	IL-5 Signaling Pathway Diagram
L1CAM Interactions Pathway antibodies	L1CAM Interactions Pathway Diagram
Neurofascin Interactions Pathway antibodies	Neurofascin Interactions Pathway Diagram
XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies	XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with Sdcbp recombinant protein

Disease Name	Pubmed Publications
Neoplasm Metastasis Antibodies	>22 publications with Sdcbp and Neoplasm Metastasis
Carcinoma Antibodies	>6 publications with Sdcbp and Carcinoma
Breast Neoplasms Antibodies	>5 publications with Sdcbp and Breast Neoplasms
Lung Neoplasms Antibodies	>4 publications with Sdcbp and Lung Neoplasms
Disease Models, Animal Antibodies	>4 publications with Sdcbp and Disease Models, Animal
Inflammation Antibodies	>4 publications with Sdcbp and Inflammation
Neoplasms, Experimental Antibodies	>3 publications with Sdcbp and Neoplasms, Experimental
Brain Diseases Antibodies	>3 publications with Sdcbp and Brain Diseases
Liver Neoplasms Antibodies	>2 publications with Sdcbp and Liver Neoplasms
Liver Diseases Antibodies	>2 publications with Sdcbp and Liver Diseases

Organs/Tissues associated with Sdcbp recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>12 publications with Sdcbp and Blood
Brain Antibodies	>11 publications with Sdcbp and Brain
Lymph Node Antibodies	>6 publications with Sdcbp and Lymph Node
Lung Antibodies	>6 publications with Sdcbp and Lung
Liver Antibodies	>5 publications with Sdcbp and Liver
Kidney Antibodies	>5 publications with Sdcbp and Kidney
Embryonic Tissue Antibodies	>5 publications with Sdcbp and Embryonic Tissue
Intestine Antibodies	>4 publications with Sdcbp and Intestine
Skin Antibodies	>4 publications with Sdcbp and Skin
Stomach Antibodies	>3 publications with Sdcbp and Stomach