Keratin 17 (KRT17) Antibody – Rabbit Polyclonal

Rabbit polyclonal to Keratin 17

Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as biomarkers (1). Mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6). Keratin 17 is involved in wound healing and cell growth, two processes that require rapid cytoskeletal remodeling (7). Keratinocytes deficient in keratin 17 exhibit abnormal Akt/mTOR signaling and fail to produce an increase in translation, cell size, or growth; these cells also exhibit abnormal 14-3-3sigma localization. As 14-3-3sigma typically associates with keratin 17, these results imply that Akt/mTOR signaling results in sequestration of 14-3-3sigma with keratin 17 in the cytosol, which is required for translation and cell growth. Phosphorylation of keratin 17 on Ser44 may provide a docking site for 14-3-3sigma binding (8).

1. Moll, R. et al. (1982) Cell 31, 11-24. 2. Chang, L. and Goldman, R.D. (2004) Nat Rev Mol Cell Biol 5, 601-13. 3. Ramaekers, F.C. and Bosman, F.T. (2004) J Pathol 204, 351-4. 4. Lane, E.B. and McLean, W.H. (2004) J Pathol 204, 355-66. 5. Zatloukal, K. et al. (2004) J Pathol 204, 367-76. 6. Owens, D.W. and Lane, E.B. (2004) J Pathol 204, 377-85. 7. Paladini, R.D. et al. (1996) J. Cell Biol. 132, 381-397.

Small volumes of anti-KRT17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125073 is an antibody targeting KRT17. Also known as Keratin 17 Rabbit pab Antibody. Reactive in Human, Rat. Host: Rabbit.