APC Antibody – Rabbit Polyclonal

The Adenomatous Polyposis Coli (APC) tumor suppressor gene is mutated in most familial and sporadic colorectal cancers and encodes a large cytoplasmic protein that is implicated in cell migration, cell adhesion, and proliferation (1). APC binds directly to microtubules and lack of APC leads to defective mitotic spindles and aneuploidy due to missegregation of chromosomes (2). APC is well characterized as a scaffolding protein, binds to betacatenin, and is involved in the regulation of its intracellular concentration. In the absence of a Wnt signal, GSK3beta phosphorylates all three members of the APCbetacateninaxin complex and this phosphorylation of betacatenin creates a recognition site for ubiquitin, the signal for proteasomemediated degradation. In the presence of a Wnt signal, dishevelled inactivates GSK3beta and betacatenin coordinates gene transcription of proteins important for the control of cell cycle progression and proliferation, such as cyclin D1 and cMyc (3).

1. Shih, I. M. et al. (2000) Cancer Res. 60, 16711676. 2. Kaplan, K. B. et al. (2001) Nat Cell Biol. 3, 429432. 3. Fodde, R. (2002) Eur J Cancer. 38, 86871.

Small volumes of anti-APC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125075 is an antibody targeting APC. Also known as APC Polyclonal Antibody. Reactive in Human, rat. Host: Rabbit.