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GPX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS125107
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This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GPX1, Polyclonal Antibody
Full Product Name
GPX1 Polyclonal Antibody
Product Gene Name
anti-GPX1 antibody
Product Synonym Names
GPXD; GSHPX1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C (regular) or -20 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
203
OMIM
138320
3D Structure
ModBase 3D Structure for P07203
Species
Human
Route
Synthetic Peptide
Immunogen
A synthetic peptide of human GPX1
Calculated Molecular Weight
22kDa

Product Categories/Family for anti-GPX1 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GPX1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
Application Notes for anti-GPX1 antibody
WB: 1:500 - 1:1000
IHC: 1:50 - 1:100
IF: 1:20 - 1:50
FC: 1:20 - 1:50

Western Blot (WB) of anti-GPX1 antibody

Western blot analysis of extracts of mouse liver, using GPX1 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Rabbit Anti-GPX1 Polyclonal Antibody – Cat# MBS125107

Other Notes

Small volumes of anti-GPX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPX1 purchase

MBS125107 is an antibody targeting GPX1. Also known as GPX1 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GPX1. It may not necessarily be applicable to this product.

NCBI GI #
311033481
NCBI GeneID
2876
NCBI Accession #
P07203.4
UniProt Primary Accession #
P07203
UniProt Secondary Accession #
Q7Z5H1; Q9BW12; E9PAS1
UniProt Related Accession #
P07203
NCBI Official Full Name
Glutathione peroxidase 1
NCBI Official Synonym Full Names
glutathione peroxidase 1
NCBI Official Symbol
GPX1
NCBI Official Synonym Symbols
GPXD; GSHPX1
UniProt Protein Name
Glutathione peroxidase 1
UniProt Synonym Protein Names
Cellular glutathione peroxidase
Protein Family
Hydroperoxy fatty acid reductase
UniProt Gene Name
GPX1
UniProt Synonym Gene Names
GPx-1; GSHPx-1
UniProt Entry Name
GPX1_HUMAN
NCBI Protein Information
glutathione peroxidase 1; GPx-1; GSHPx-1; cellular glutathione peroxidase

UniProt Comments for GPX1

GPX1: Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family.

Protein type: Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.11.1.9; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; cytosol; nucleus

Molecular Function: selenium binding; glutathione binding; phospholipid-hydroperoxide glutathione peroxidase activity; glutathione peroxidase activity; SH3 domain binding

Biological Process: fat cell differentiation; response to nicotine; blood vessel endothelial cell migration; response to toxin; myoblast proliferation; skeletal muscle fiber development; negative regulation of caspase activity; thermoregulation; vasodilation; regulation of gene expression, epigenetic; endothelial cell development; response to estradiol stimulus; regulation of mammary gland epithelial cell proliferation; response to selenium ion; glutathione metabolic process; sensory perception of sound; response to symbiotic bacterium; UV protection; lipoxygenase pathway; hydrogen peroxide catabolic process; response to folic acid; regulation of neuron apoptosis; response to glucose stimulus; arachidonic acid metabolic process; response to gamma radiation; negative regulation of inflammatory response to antigenic stimulus; aging; protein amino acid oxidation; nucleobase, nucleoside and nucleotide metabolic process; skeletal muscle regeneration; angiogenesis involved in wound healing; purine base metabolic process; positive regulation of protein kinase B signaling cascade; response to xenobiotic stimulus; response to reactive oxygen species; triacylglycerol metabolic process; response to hydrogen peroxide; cell redox homeostasis; response to lipid hydroperoxide; heart contraction; purine nucleotide catabolic process; interaction with symbiont; induction of apoptosis by oxidative stress

Disease: Glutathione Peroxidase Deficiency
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Research Articles on GPX1

1. Study supports the notion that SOD and GSH-Px polymorphisms are involved in Celiac disease development, even though findings were not statistically significant.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GPX1 antibody

 Reference Product  PubMed Publications
 GSTP1 antibody  >26 publications with GPX1 and GSTP1
 GSR antibody  >23 publications with GPX1 and GSR
 GSS antibody  >8 publications with GPX1 and GSS
 GSTA1 antibody  >5 publications with GPX1 and GSTA1
 GSTM2 antibody  >4 publications with GPX1 and GSTM2
 GSTA4 antibody  >4 publications with GPX1 and GSTA4
 GSTA2 antibody  >1 publications with GPX1 and GSTA2

Pathways associated with anti-GPX1 antibody

 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram

Diseases associated with anti-GPX1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >104 publications with GPX1 and Cardiovascular Diseases
 Inflammation Antibodies  >84 publications with GPX1 and Inflammation
 Liver Diseases Antibodies  >55 publications with GPX1 and Liver Diseases
 Heart Diseases Antibodies  >47 publications with GPX1 and Heart Diseases
 Necrosis Antibodies  >45 publications with GPX1 and Necrosis
 Breast Neoplasms Antibodies  >29 publications with GPX1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >28 publications with GPX1 and Lung Neoplasms
 Atherosclerosis Antibodies  >27 publications with GPX1 and Atherosclerosis
 Liver Neoplasms Antibodies  >23 publications with GPX1 and Liver Neoplasms
 Hyperglycemia Antibodies  >22 publications with GPX1 and Hyperglycemia

Organs/Tissues associated with anti-GPX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >275 publications with GPX1 and Blood
 Liver Antibodies  >213 publications with GPX1 and Liver
 Muscle Antibodies  >106 publications with GPX1 and Muscle
 Brain Antibodies  >93 publications with GPX1 and Brain
 Heart Antibodies  >83 publications with GPX1 and Heart
 Lung Antibodies  >79 publications with GPX1 and Lung
 Vascular Antibodies  >73 publications with GPX1 and Vascular
 Kidney Antibodies  >73 publications with GPX1 and Kidney
 Intestine Antibodies  >43 publications with GPX1 and Intestine
 Prostate Antibodies  >35 publications with GPX1 and Prostate
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