Glycerol 2-Dehydrogenase (NADP(+) (GCY1) Saccharomyces Cerevisiae Recombinant Protein

Glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. Has mRNA binding activity.

A nuclear yeast gene (GCY) encodes a polypeptide with high homology to a vertebrate eye lens protein.Oechsner U., Magdolen V., Bandlow W.FEBS Lett. 238:123-128(1988) The type of basal promoter determines the regulated or constitutive mode of transcription in the common control region of the yeast gene pair GCY1/RIO1.Angermayr M., Bandlow W.J. Biol. Chem. 272:31630-31635(1997) Sequencing and analysis of 51 kb on the right arm of chromosome XV from Saccharomyces cerevisiae reveals 30 open reading frames.Wiemann S., Rechmann S., Benes V., Voss H., Schwager C., Vlcek C., Stegemann J., Zimmermann J., Erfle H., Paces V., Ansorge W.3.0.CO;2-O>Yeast 12:281-288(1996) DNA sequencing and analysis of 130 kb from yeast chromosome XV.Voss H., Benes V., Andrade M.A., Valencia A., Rechmann S., Teodoru C., Schwager C., Paces V., Sander C., Ansorge W.3.0.CO;2-I>Yeast 13:655-672(1997) The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.Nature 387:98-102(1997) ) Transcriptional control by galactose of a yeast gene encoding a protein homologous to mammalian aldo/keto reductases.Magdolen V., Oechsner U., Trommler P., Bandlow W.Gene 90:105-114(1990) Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway.Norbeck J., Blomberg A.J. Biol. Chem. 272:5544-5554(1997) The general regulatory factor Reb1p controls basal, but not Gal4p-mediated, transcription of the GCY1 gene in yeast.Angermayr M., Bandlow W.Mol. Gen. Genet. 256:682-689(1997) Crystallization and aldo-keto reductase activity of Gcy1p from Saccharomyces cerevisiae.Hur E., Wilson D.K.Acta Crystallogr. D 56:763-765(2000) Microaerobic glycerol formation in Saccharomyces cerevisiae.Costenoble R., Valadi H., Gustafsson L., Niklasson C., Franzen C.J.3.3.CO;2-B>Yeast 16:1483-1495(2000) Functional genomic studies of aldo-keto reductases.Petrash J.M., Murthy B.S., Young M., Morris K., Rikimaru L., Griest T.A., Harter T.Chem. Biol. Interact. 130:673-683(2001) Permanent nucleosome exclusion from the Gal4p-inducible yeast GCY1 promoter.Angermayr M., Bandlow W.J. Biol. Chem. 278:11026-11031(2003) Intracellular glycerol influences resistance to freeze stress in Saccharomyces cerevisiae analysis of a quadruple mutant in glycerol dehydrogenase genes and glycerol-enriched cells.Izawa S., Sato M., Yokoigawa K., Inoue Y.Appl. Microbiol. Biotechnol. 66:108-114(2004) Functional studies of aldo-keto reductases in Saccharomyces cerevisiae.Chang Q., Griest T.A., Harter T.M., Petrash J.M.Biochim. Biophys. Acta 1773:321-329(2007) Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.Science 325:1682-1686(2009) Proteome-wide search reveals unexpected RNA-binding proteins in Saccharomyces cerevisiae.Tsvetanova N.G., Klass D.M., Salzman J., Brown P.O.PLoS ONE 5:E12671-E12671(2010) Characterization of GCY1 in Saccharomyces cerevisiae by metabolic profiling.Jung J.Y., Kim T.Y., Ng C.Y., Oh M.K.J. Appl. Microbiol. 113:1468-1478(2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.Tkach J.M., Yimit A., Lee A.Y., Riffle M., Costanzo M., Jaschob D., Hendry J.A., Ou J., Moffat J., Boone C., Davis T.N., Nislow C., Brown G.W.Nat. Cell Biol. 14:966-976(2012) Engineering of the glycerol decomposition pathway and cofactor regulation in an industrial yeast improves ethanol production.Zhang L., Tang Y., Guo Z., Shi G.J. Ind. Microbiol. Biotechnol. 40:1153-1160(2013) Development of a bioconversion system using Saccharomyces cerevisiae reductase YOR120W and Bacillus subtilis glucose dehydrogenase for chiral alcohol synthesis.Yoon S.A., Kim H.K.J. Microbiol. Biotechnol. 23:1395-1402(2013)

Small volumes of GCY1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1251522 is a recombinant protein targeting GCY1. Also known as Recombinant Saccharomyces cerevisiae Glycerol 2-dehydrogenase (NADP(+). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.