FGF Receptor 2 (FGFR2) Antibody – Rabbit Polyclonal

Rabbit polyclonal to FGF Receptor 2

Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3, and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma (4,5).

1. Powers, C.J. et al. (2000) Endocr Relat Cancer 7, 165-97. 2. Reilly, J.F. et al. (2000) J Biol Chem 275, 7771-8. 3. Mohammadi, M. et al. (1996) Mol Cell Biol 16, 977-89. 4. Mohammadi, M. et al. (1991) Mol Cell Biol 11, 5068-78. 5. Larsson, H. et al. (1999) J Biol Chem 274, 25726-34.

Small volumes of anti-FGFR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125218 is an antibody targeting FGFR2. Also known as FGF Receptor 2 Rabbit pab Antibody. Reactive in Human, mouse, rat. Host: Rabbit.