Dog HTR2A Recombinant Protein – Cat# MBS1253625

5-Hydroxytryptamine Receptor 2a (HTR2A) Dog Recombinant Protein

Name: HTR2A Recombinant Protein; 5-Hydroxytryptamine Receptor 2a; Dog; MyBioSource
Brand: MyBioSource
SKU: MBS1253625
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1253625

MBS1253625 is a recombinant protein targeting HTR2A. Also known as Recombinant Dog 5-hydroxytryptamine receptor 2A (HTR2A). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

5-hydroxytryptamine receptor 2A (HTR2A), Recombinant Protein

Full Product Name

Recombinant Dog 5-hydroxytryptamine receptor 2A (HTR2A)

Product Gene Name

HTR2A recombinant protein

Product Synonym Gene Name

HTR2A; 5-HTR2A

Product Synonym Names

Recombinant 5-hydroxytryptamine receptor 2A (HTR2A); 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; 5-hydroxytryptamine receptor; Serotonin receptor 2A

Sequence

MDVLFEDNAP LSPTTSSLMP SNGDPRLYGN DLNAGDANTS DAFNWTVDAE NRTNLSCEGC LSPPCFSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM VITYFLTIKS LQKEATLCVS DPGTRAKLAS FSFLPQSSLS SEKLFQRSIH REPGSYGRRT MQSISNEQKA CKVLGIVFFL FVVMWCPFFI TNIMAVICKE SCNEDIIGAL LNVFVWIGYL SSAVNPLVYT LFNKTYRSAF SRYIQCQYKE NKKPLQLILV NTIPALAYKS SQLQMGQKKN SKKDAKSTDN DYSMVALGKQ HSEDAPTDNI NTVNEKVSCV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

52,378 Da

Sequence Positions

1-470

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 22; NC_006604.3 (4453715..4510934). Location: chromosome: 22

3D Structure

ModBase 3D Structure for O46635

Species

Canis familiaris (Dog) (Canis lupus familiaris)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HTR2A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HTR2A. It may not necessarily be applicable to this product.

NCBI GI #

54607157

NCBI GeneID

403882

NCBI Accession #

NP_001005869.1

UniProt Primary Accession #

O46635

UniProt Secondary Accession #

Q50DZ9; Q60F96

UniProt Related Accession #

O46635

GenBank Nucleotide #

NM_001005869.1

NCBI Official Full Name

5-hydroxytryptamine receptor 2A

NCBI Official Symbol

HTR2A

NCBI Official Synonym Symbols

5-HT-2; 5-HT-2A; 5-HTR2A

UniProt Protein Name

5-hydroxytryptamine receptor 2A

UniProt Synonym Protein Names

Serotonin receptor 2A

UniProt Gene Name

HTR2A

UniProt Synonym Gene Names

5-HTR2A; 5-HT-2; 5-HT-2A

UniProt Entry Name

5HT2A_CANFA

NCBI Protein Information

5-hydroxytryptamine receptor 2A; 5HT2A receptor; serotonin receptor 2A

UniProt Comments for HTR2A

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production

By similarity.

Subunit structure: Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein

By similarity. Note: Localizes to the postsynaptic thickening of axo-dendritic synapses

By similarity.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Research Articles on HTR2A

1. 5HT2A receptor inhibition with APD791, even when initiated after the onset of recurrent thrombosis, improves coronary patency in the in vivo canine model.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HTR2A recombinant protein

Products by Pathway	Pathway Diagram
Amine Ligand-binding Receptors Pathway antibodies	Amine Ligand-binding Receptors Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gap Junction Pathway antibodies	Gap Junction Pathway Diagram
Gap Junction Pathway antibodies	Gap Junction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with HTR2A recombinant protein

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>184 publications with HTR2A and Mental Disorders
Schizophrenia Antibodies	>74 publications with HTR2A and Schizophrenia
Mood Disorders Antibodies	>66 publications with HTR2A and Mood Disorders
Depressive Disorder Antibodies	>47 publications with HTR2A and Depressive Disorder
Nervous System Diseases Antibodies	>37 publications with HTR2A and Nervous System Diseases
Depressive Disorder, Major Antibodies	>32 publications with HTR2A and Depressive Disorder, Major
Bipolar Disorder Antibodies	>25 publications with HTR2A and Bipolar Disorder
Anxiety Disorders Antibodies	>23 publications with HTR2A and Anxiety Disorders
Affective Disorders, Psychotic Antibodies	>22 publications with HTR2A and Affective Disorders, Psychotic
Serotonin Syndrome Antibodies	>20 publications with HTR2A and Serotonin Syndrome