SMAD2 Antibody – Rabbit Polyclonal

Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-beta signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the commonmediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 (1-5). Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy-terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses (6-8).

1. Heldin, C.H. et al. (1997) Nature 390, 465-471. 2. Attisano, L. and Wrana, J.L. (1998) Curr. Opin. Cell Biol. 10, 188-194. 3. Derynck, R. et al. (1998) Cell 95, 737-740. 4. Massague, J. (1998) Annu. Rev. Biochem. 67, 753-791. 5. Whitman, M. (1998) Genes Dev. 12, 2445-2462. 6. Wu, G. et al. (2000) Science 287, 92-97. 7. Attisano, L. and Wrana, J.L. (2002) Science 296, 1646-1647. 8. Moustakas, A. et al. (2001) J. Cell Sci. 114, 4359-4369.

Small volumes of anti-SMAD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125476 is an antibody targeting SMAD2. Also known as Smad2 Polyclonal Antibody. Reactive in Human, rat. Host: Rabbit.