TP63 Antibody – Rabbit Polyclonal

Rabbit polyclonal to p63

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in both structure and function (2). While p63 can induce p53-responsive genes and apoptosis, mutation of p63 rarely results in tumors (2). Amplification of the p63 gene is frequently observed in squamous cell carcinomas of the lung, head and neck (2,3). The p63 gene contains an alternative transcription intiation site that yields a 40 kDa deltaNp63 lacking the transactivation domain, and alternative splicing at the carboxy-terminus yields the alpha, beta and gamma isoforms (3,4).

1. Levine, A. J. et al. (1997) Cell 88, 323-331. 2. Waltermann, A. et al. (2003) Oncogene 22, 5686-5693. 3. Hibi, K. et al. (2000) Proc. Natl. Acad. Sci. USA 97, 5462-5467. 4. Yang, A. et al. (1999) Nature 398, 714-718.

Small volumes of anti-TP63 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125652 is an antibody targeting TP63. Also known as p63 Rabbit pab Antibody. Reactive in Human, mouse, rat. Host: Rabbit.