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A-Kinase Anchor Protein 5 (AKAP5) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1256523

MBS1256523 is a recombinant protein targeting AKAP5. Also known as Recombinant Human A-kinase anchor protein 5 (AKAP5). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1170 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
A-kinase anchor protein 5 (AKAP5), Recombinant Protein
Full Product Name
Recombinant Human A-kinase anchor protein 5 (AKAP5)
Product Gene Name
AKAP5 recombinant protein
Sequence
METTISEIHV ENKDEKRSAE GSPGAERQKE KASMLCFKRR KKAAKALKPK AGSEAADVAR KCPQEAGASD QPEPTRGAWA SLKRLVTRRK RSESSKQQKP LEGEMQPAIN AEDADLSKKK AKSRLKIPCI KFPRGPKRSN HSKIIEDSDC SIKVQEEAEI LDIQTQTPLN DQATKAKSTQ DLSEGISRKD GDEVCESNVS NSTTSGEKVI SVELGLDNGH SAIQTGTLIL EEIETIKEKQ DVQPQQASPL ETSETDHQQP VLSDVPPLPA IPDQQIVEEA SNSTLESAPN GKDYESTEIV AEETKPKDTE LSQESDFKEN GITEEKSKSE ESKRMEPIAI IITDTEISEF DVTKSKNVPK QFLISAENEQ VGVFANDNGF EDRTSEQYET LLIETASSLV KNAIQLSIEQ LVNEMASDDN KINNLLQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
47,088 Da
Sequence Positions
1-427, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
604688
3D Structure
ModBase 3D Structure for P24588
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of AKAP5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AKAP5. It may not necessarily be applicable to this product.

NCBI GI #
158187521
NCBI GeneID
9495
NCBI Accession #
NP_004848.3
UniProt Primary Accession #
P24588
UniProt Secondary Accession #
A2RRB8
UniProt Related Accession #
P24588
GenBank Nucleotide #
NM_004857.3
NCBI Official Full Name
A-kinase anchor protein 5
NCBI Official Synonym Full Names
A-kinase anchoring protein 5
NCBI Official Symbol
AKAP5
NCBI Official Synonym Symbols
H21; AKAP75; AKAP79
UniProt Protein Name
A-kinase anchor protein 5
UniProt Synonym Protein Names
A-kinase anchor protein 79 kDa; AKAP 79; H21; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
Protein Family
A-kinase anchor protein
UniProt Gene Name
AKAP5
UniProt Synonym Gene Names
AKAP79; AKAP-5; AKAP 79
NCBI Protein Information
A-kinase anchor protein 5

NCBI Summary for AKAP5

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]
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UniProt Comments for AKAP5

May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
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Research Articles on AKAP5

1. Studies indicate the importance of the AKAP79/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 region of the hippocampus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AKAP5 recombinant protein

 Reference Product  PubMed Publications
 ADRB2 recombinant protein  >5 publications with AKAP5 and ADRB2
 PRKCA recombinant protein  >3 publications with AKAP5 and PRKCA
 PRKAR2B recombinant protein  >3 publications with AKAP5 and PRKAR2B
 PRKAR2A recombinant protein  >3 publications with AKAP5 and PRKAR2A
 IQGAP1 recombinant protein  >1 publications with AKAP5 and IQGAP1
 DLG4 recombinant protein  >1 publications with AKAP5 and DLG4
 DLG1 recombinant protein  >1 publications with AKAP5 and DLG1

Pathways associated with AKAP5 recombinant protein

 Products by Pathway  Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
 Regulation Of Insulin Secretion By Glucagon-like Peptide-1 Pathway antibodies  Regulation Of Insulin Secretion By Glucagon-like Peptide-1 Pathway Diagram
 Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway antibodies  Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway Diagram

Diseases associated with AKAP5 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with AKAP5 and Nervous System Diseases
 Seizures Antibodies  >4 publications with AKAP5 and Seizures
 Cardiomegaly Antibodies  >4 publications with AKAP5 and Cardiomegaly
 Cardiovascular Abnormalities Antibodies  >2 publications with AKAP5 and Cardiovascular Abnormalities
 Congenital Abnormalities Antibodies  >2 publications with AKAP5 and Congenital Abnormalities
 Inflammation Antibodies  >2 publications with AKAP5 and Inflammation
 Memory Disorders Antibodies  >2 publications with AKAP5 and Memory Disorders
 Acidosis Antibodies  >1 publications with AKAP5 and Acidosis
 Learning Disorders Antibodies  >1 publications with AKAP5 and Learning Disorders
 Motor Skills Disorders Antibodies  >1 publications with AKAP5 and Motor Skills Disorders

Organs/Tissues associated with AKAP5 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >61 publications with AKAP5 and Brain
 Kidney Antibodies  >6 publications with AKAP5 and Kidney
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