BMP4 Antibody – Rabbit Polyclonal

Rabbit polyclonal to Human BMP4

Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation (1,2). BMPs belongs to the TGF-beta superfamily, playing many diverse functions during development (3). BMPs are synthesized as precursor proteins and then processed by cleavage to release the c-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5 and 8), resulting the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems (3,4). BMP4 plays an essential role during development. Mouse embyros deficient in BMP4 die around the time of gastrulation (5). BMP4 regulates stem cell maintenance and differentiation in various systems (6-8).

1. Wang, E.A. et al. (1988) Proc Natl Acad Sci USA 85, 9484-8. 2. Wozney, J.M. et al. (1988) Science 242, 1528-34. 3. Kawabata, M. et al. (1998) Cytokine Growth Factor Rev 9, 49-61. 4. Nohe, A. et al. (2004) Cell Signal 16, 291-9. 5. Dunn, N.R. et al. (1997) Dev Biol 188, 235-47. 6. Nakayama, N. et al. (2000) Blood 95, 2275-83. 7. Solmesky, L.J. et al. (2009) Stem Cells Dev 18, 1283-92. 8. Goldman, O. et al. (2009) Stem Cells 27, 1750-9.

Small volumes of anti-BMP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125763 is an antibody targeting BMP4. Also known as BMP4 Rabbit pab Antibody. Reactive in Human. Host: Rabbit.