Cyclin D1 (CCND1) Antibody – Rabbit Polyclonal

Activity of the cyclindependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip/Kip or INK family of proteins (1). The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to effect progression through the restriction point and pRbdependent entry into Sphase (2). The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/Sphase gene expression (3). Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of its protein expression and through phosphorylation-dependent degradation (4).

1. Hirai, H. et al. (1995) Mol. Cell. Biol. 15, 2672-2681. 2. Sherr, C.J. (1996) Science 274, 1672-1677. 3. Lukas, J. et al. (1996) Mol. Cell. Biol. 16, 6917-6925. 4. Diehl, J.A. et al. (1997) Genes Dev. 11, 957-972.

Small volumes of anti-CCND1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125892 is an antibody targeting CCND1. Also known as Cyclin D1 Polyclonal Antibody. Reactive in Human, mouse, rat. Host: Rabbit.