RAC2 Antibody – Rabbit Polyclonal

Rabbit polyclonal to Human Rac2

Rac and Cdc42 are members of the Rho-GTPase family. In mammals, Rac exists as three isoforms, Rac1, Rac2 and Rac3, which are highly similar in sequence. Rac1 and Cdc42, the most widely studied of this group, are ubiquitously expressed. Rac2 is expressed in cells of hematopoietic origin, and Rac3, while highly expressed in brain, is also found in many other tissues. Rac and Cdc42 play key signaling roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation, cell growth and development (1). GTP binding stimulates the activity of Rac/Cdc42, and the hydrolysis of GTP to GDP through the protein's intrinsic GTPase activity, rendering it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs). Another level of regulation is achieved through the binding of RhoGDI, a guanine nucleotide dissociation inhibitor, which retains Rho family GTPases, including Rac and Cdc42, in their inactive GDP-bound state (2,3).

1. Wennerberg, K. and Der, C.J. (2004) J Cell Sci 117, 1301-12. 2. Bernards, A. and Settleman, J. (2004) Trends Cell Biol 14, 377-85. 3. Rossman, K.L. et al. (2005) Nat Rev Mol Cell Biol 6, 167-80.

Small volumes of anti-RAC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS126035 is an antibody targeting RAC2. Also known as Rac2 Rabbit pab Antibody. Reactive in Human, mouse. Host: Rabbit.