Rabbit Anti-ITGB4 Polyclonal Antibody – Cat# MBS126040

Western blot analysis of extracts of various cell lines, using ITGB4 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.

ITGB4 Antibody – Rabbit Polyclonal

Name: ITGB4 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS126040
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS126040

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities.… More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ITGB4, Polyclonal Antibody

Full Product Name

ITGB4 Polyclonal Antibody

Product Gene Name

anti-ITGB4 antibody

Product Synonym Names

Integrin beta4: Integrin b4; CD104

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

PBS with 0.09% Sodium azide,50% glycerol,pH7.3.

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

1822

OMIM

phenotype 226730

3D Structure

ModBase 3D Structure for P16144

Species

Human

Immunogen

Recombinant protein of human ITGB4

Calculated Molecular Weight

195kDa

Product Categories/Family for anti-ITGB4 antibody

Polyclonal

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-ITGB4 antibody

Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

Application Notes for anti-ITGB4 antibody

WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:100

Other Notes

Small volumes of anti-ITGB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITGB4 purchase

MBS126040 is an antibody targeting ITGB4. Also known as ITGB4 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGB4. It may not necessarily be applicable to this product.

NCBI GI #

317373584

NCBI GeneID

3691

NCBI Accession #

P16144.5

UniProt Primary Accession #

P16144

UniProt Secondary Accession #

O14690; O14691; O15339; O15340; O15341; Q0VF97; Q9UIQ4; A0AVL6

UniProt Related Accession #

P16144

NCBI Official Full Name

Integrin beta-4

NCBI Official Synonym Full Names

integrin, beta 4

NCBI Official Symbol

ITGB4

NCBI Official Synonym Symbols

CD104

UniProt Protein Name

Integrin beta-4

UniProt Synonym Protein Names

GP150; CD_antigen: CD104

Protein Family

Integrin

UniProt Gene Name

ITGB4

UniProt Entry Name

ITB4_HUMAN

NCBI Protein Information

integrin beta-4; GP150; CD104 antigen; integrin beta-4 subunit

UniProt Comments for ITGB4

ITGB4: integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cell surface; hemidesmosome; leading edge; basal plasma membrane; plasma membrane; basement membrane; integrin complex; receptor complex

Molecular Function: protein binding; G-protein-coupled receptor binding; receptor activity

Biological Process: skin development; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; hemidesmosome assembly; filopodium formation; gut development; cell-matrix adhesion; cell motility involved in cell locomotion; response to wounding; autophagy; mesodermal cell differentiation; cell adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Junctionalis With Pyloric Atresia

Research Articles on ITGB4

1. the diminishment of crosstalk between phosphorylated FAK and ITGB4 due to the down-regulation of Gli family transcription factors might play a pivotal role for inhibiting ovarian cancer progression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITGB4 antibody

Reference Product	PubMed Publications
MET antibody	>25 publications with ITGB4 and MET
PLEC antibody	>22 publications with ITGB4 and PLEC
ITGA6 antibody	>20 publications with ITGB4 and ITGA6
ITGA3 antibody	>8 publications with ITGB4 and ITGA3
GRB2 antibody	>7 publications with ITGB4 and GRB2
COL17A1 antibody	>6 publications with ITGB4 and COL17A1
SHC1 antibody	>4 publications with ITGB4 and SHC1
PRKCA antibody	>3 publications with ITGB4 and PRKCA

Pathways associated with anti-ITGB4 antibody

Products by Pathway	Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram

Diseases associated with anti-ITGB4 antibody

Disease Name	Pubmed Publications
Epidermolysis Bullosa Antibodies	>76 publications with ITGB4 and Epidermolysis Bullosa
Adenocarcinoma Antibodies	>60 publications with ITGB4 and Adenocarcinoma
Breast Neoplasms Antibodies	>60 publications with ITGB4 and Breast Neoplasms
Epidermolysis Bullosa, Junctional Antibodies	>50 publications with ITGB4 and Epidermolysis Bullosa, Junctional
Pyloric Atresia Antibodies	>43 publications with ITGB4 and Pyloric Atresia
Carcinoma, Squamous Cell Antibodies	>41 publications with ITGB4 and Carcinoma, Squamous Cell
Inflammation Antibodies	>34 publications with ITGB4 and Inflammation
Lung Diseases Antibodies	>33 publications with ITGB4 and Lung Diseases
Lung Neoplasms Antibodies	>33 publications with ITGB4 and Lung Neoplasms
Neoplasms, Experimental Antibodies	>31 publications with ITGB4 and Neoplasms, Experimental

Organs/Tissues associated with anti-ITGB4 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>151 publications with ITGB4 and Skin
Vascular Antibodies	>102 publications with ITGB4 and Vascular
Eye Antibodies	>66 publications with ITGB4 and Eye
Lung Antibodies	>58 publications with ITGB4 and Lung
Nerve Antibodies	>58 publications with ITGB4 and Nerve
Mouth Antibodies	>51 publications with ITGB4 and Mouth
Embryonic Tissue Antibodies	>48 publications with ITGB4 and Embryonic Tissue
Stomach Antibodies	>38 publications with ITGB4 and Stomach
Prostate Antibodies	>30 publications with ITGB4 and Prostate
Liver Antibodies	>29 publications with ITGB4 and Liver