Tetanus Toxin (tetX) Clostridium Tetani Recombinant Protein

Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.

Tetanus toxin primary structure, expression in E. coli, and homology with botulinum toxins.Eisel U., Jarausch W., Goretzki K., Henschen A., Engels J., Weller U., Hudel M., Habermann E., Niemann H.EMBO J. 5:2495-2502(1986) The complete nucleotide sequence of tetanus toxin.Fairweather N.F., Lyness V.A.Nucleic Acids Res. 14:7809-7812(1986) The genome sequence of Clostridium tetani, the causative agent of tetanus disease.Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) Cloning, nucleotide sequencing, and expression of tetanus toxin fragment C in Escherichia coli.Fairweather N.F., Lyness V.A., Pickard D.J., Allen G., Thomson R.O.J. Bacteriol. 165:21-27(1986) Arrangement of disulfide bridges and positions of sulfhydryl groups in tetanus toxin.Krieglstein K., Henschen A., Weller U., Habermann E.Eur. J. Biochem. 188:39-45(1990) Limited proteolysis of tetanus toxin. Relation to activity and identification of cleavage sites.Krieglstein K.G., Henschen A.H., Weller U., Habermann E.Eur. J. Biochem. 202:41-51(1991) Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.Schiavo G., Poulain B., Rossetto O., Benfenati F., Tauc L., Montecucco C.EMBO J. 11:3577-3583(1992) Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin.Schiavo G., Benfenati F., Poulain B., Rossetto O., de Laureto P.P., Dasgupta B.R., Montecucco C.Nature 359:832-835(1992) Structure of the receptor binding fragment HC of tetanus neurotoxin.Umland T.C., Wingert L.M., Swaminathan S., Furey W.F. Jr., Schmidt J.J., Sax M.Nat. Struct. Biol. 4:788-792(1997)

Small volumes of tetX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1262435 is a recombinant protein targeting tetX. Also known as Recombinant Clostridium tetani Tetanus toxin (tetX), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.