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Alpha-1a Adrenergic Receptor (ADRA1A) Dog Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1262703

MBS1262703 is a recombinant protein targeting ADRA1A. Also known as Recombinant Dog Alpha-1A adrenergic receptor (ADRA1A). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Alpha-1A adrenergic receptor (ADRA1A), Recombinant Protein
Full Product Name
Recombinant Dog Alpha-1A adrenergic receptor (ADRA1A)
Product Gene Name
ADRA1A recombinant protein
Product Synonym Gene Name
ADRA1A; ADRA1C
Product Synonym Names
Recombinant Alpha-1A adrenergic receptor (ADRA1A); Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor Alpha-1C adrenergic receptor
Sequence
MVFLSGNASD SSNCTHPPAP VNISKAILLG VILGGLIIFG VLGNILVILS VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ KRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQITE EPGYVLFSAL GSFYVPLTII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN APVGGTGVSS AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIG
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
32,254 Da
Sequence Positions
1-295
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 25; NC_006607.3 (30693571..30795394). Location: chromosome: 25
3D Structure
ModBase 3D Structure for O77621
Species
Canis familiaris (Dog) (Canis lupus familiaris)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ADRA1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ADRA1A. It may not necessarily be applicable to this product.

NCBI GI #
5902693
NCBI GeneID
403866
NCBI Accession #
O77621.1
UniProt Primary Accession #
O77621
UniProt Related Accession #
O77621
NCBI Official Full Name
Alpha-1A adrenergic receptor
NCBI Official Symbol
ADRA1A
NCBI Official Synonym Symbols
ADRA1C; ALPHA-1A
UniProt Protein Name
Alpha-1A adrenergic receptor
UniProt Synonym Protein Names
Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor
Protein Family
Alpha-1A adrenergic receptor
UniProt Gene Name
ADRA1A
UniProt Synonym Gene Names
ADRA1C; Alpha-1A adrenoceptor
UniProt Entry Name
ADA1A_CANFA
NCBI Protein Information
alpha-1A adrenergic receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor; adrenergic, alpha-1A-, receptor

UniProt Comments for ADRA1A

Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes

By similarity.

Subunit structure: Homo- and heterooligomer

By similarity. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes

By similarity.

Subcellular location: Nucleus membrane; Multi-pass membrane protein

By similarity. Cell membrane; Multi-pass membrane protein

By similarity. Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes

By similarity.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ADRA1A recombinant protein

 Products by Pathway  Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Organs/Tissues associated with ADRA1A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >15 publications with ADRA1A and Testis
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