RPS3 Antibody – Rabbit Polyclonal

RPS3: a component of the 40S ribosomal subunit of eukaryotes. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Overexpressed in colorectal cancer.

Protein type: EC 4.2.99.18; Ribosomal; Translation; RNA-binding; Apoptosis

Chromosomal Location of Human Ortholog: 11q13.3-q13.5

Cellular Component: focal adhesion; membrane; mitochondrial inner membrane; cytoplasm; nucleolus; spindle; ribonucleoprotein complex; nucleus; cytosol

Molecular Function: mRNA binding; NF-kappaB binding; protein binding; DNA-(apurinic or apyrimidinic site) lyase activity; enzyme binding; structural constituent of ribosome; protein kinase A binding; oxidized purine base lesion DNA N-glycosylase activity; iron-sulfur cluster binding; damaged DNA binding; protein kinase binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; mitosis; viral reproduction; transcription, DNA-dependent; translation; apoptosis; viral infectious cycle; translational termination; DNA repair; DNA catabolic process, endonucleolytic; activation of NF-kappaB transcription factor; regulation of translation; cellular protein metabolic process; translational elongation; cell division; translational initiation; mRNA catabolic process, nonsense-mediated decay; viral transcription; gene expression; response to DNA damage stimulus; negative regulation of DNA repair