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Kappa-Theraphotoxin-Hm2a (KAPPA-TRTX-HM2A) Heteroscodra Maculata Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1263623

MBS1263623 is a recombinant protein targeting Kappa-TRTX-Hm2a. Also known as Recombinant Heteroscodra maculata Kappa-theraphotoxin-Hm2a. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$640 / 0.05 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Kappa-theraphotoxin-Hm2a (Kappa-TRTX-Hm2a), Recombinant Protein
Full Product Name
Recombinant Heteroscodra maculata Kappa-theraphotoxin-Hm2a
Product Synonym Names
Recombinant Kappa-theraphotoxin-Hm2a; Kappa-theraphotoxin-Hm2a; Kappa-TRTX-Hm2a; Heteroscodratoxin-2 HmTx2
Sequence
ECRYFWGECN DEMVCCEHLV CKEKWPITYK ICVWDRTF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
4,765 Da
Sequence Positions
1-38aa; Cytoplasmic domain
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P60993
Species
Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Kappa-TRTX-Hm2a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Kappa-TRTX-Hm2a. It may not necessarily be applicable to this product.

NCBI GI #
NCBI Accession #
UniProt Primary Accession #
NCBI Official Full Name
Kappa-theraphotoxin-Hm2a
UniProt Protein Name
Kappa-theraphotoxin-Hm2a
UniProt Synonym Protein Names
Heteroscodratoxin-2; HmTx2
Protein Family
UniProt Gene Name
Kappa-TRTX-Hm2a
UniProt Synonym Gene Names
Kappa-TRTX-Hm2a
UniProt Entry Name
TX2_HETMC

UniProt Comments for Kappa-TRTX-Hm2a

Function: Inhibitor of voltage-gated potassium channels. It specifically inhibits Kv2.1/KCNB1 channels. Ref.1

Subcellular location: Secreted.

Tissue specificity: Expressed by the venom gland.

Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin

By similarity.

Miscellaneous: Percentage of current inhibition is 18% on Kv2.1/KCNB1 at 300 nM. Has no activity on Kv2.2/KCNB2, Kv4.1/KCND1, Kv4.2/KCND2 and Kv4.3/KCND3. Intracerebroventricular injection into mice does not induce observable neurotoxicity symptoms (Ref.1).

Sequence similarities: Belongs to the huwentoxin-1 family.

Mass spectrometry: Molecular mass is 4754.09 Da from positions 1 - 38. Determined by MALDI. Ref.1
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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