CX3C Chemokine Receptor 1 (CX3CR1) Rat Recombinant Protein

CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Cell adhesion; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, cytokine; Receptor, GPCR

Cellular Component: neuron projection; perinuclear region of cytoplasm; integral to membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; C-X3-C chemokine receptor activity

Biological Process: positive regulation of neuroblast proliferation; cytokine and chemokine mediated signaling pathway; microglial cell activation; macrophage chemotaxis; memory; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of angiogenesis; negative regulation of chronic inflammatory response to non-antigenic stimulus; cerebral cortex cell migration; cell adhesion; negative regulation of cell migration; microglial cell activation during immune response