PTGER4 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

PTGER4: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; prostaglandin E receptor activity

Biological Process: T-helper cell differentiation; negative regulation of cytokine secretion; response to lipopolysaccharide; negative regulation of integrin activation; G-protein signaling, coupled to cAMP nucleotide second messenger; response to mechanical stimulus; regulation of stress fiber formation; negative regulation of inflammatory response; JNK cascade; immune response; regulation of ossification; positive regulation of cytokine secretion; positive regulation of inflammatory response