C-C Motif Chemokine 2 (CCL2) Antibody – Rabbit Polyclonal

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: dendrite; endocytic vesicle; extracellular region; extracellular space; nerve terminal; perikaryon; perinuclear region of cytoplasm; rough endoplasmic reticulum; synapse

Molecular Function: CCR2 chemokine receptor binding; chemokine activity; heparin binding; protein kinase activity; receptor binding

Biological Process: aging; angiogenesis; astrocyte cell migration; cell adhesion; cell surface receptor linked signal transduction; cellular calcium ion homeostasis; cellular homeostasis; cellular protein metabolic process; cellular response to insulin stimulus; chemotaxis; cytokine and chemokine mediated signaling pathway; cytoskeleton organization and biogenesis; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; humoral immune response; inflammatory response; JAK-STAT cascade; leukocyte migration during inflammatory response; lipopolysaccharide-mediated signaling pathway; lymphocyte chemotaxis; macrophage chemotaxis; MAPKKK cascade; maternal process involved in parturition; maternal process involved in pregnancy; monocyte chemotaxis; negative regulation of angiogenesis; negative regulation of neuron apoptosis; neutrophil chemotaxis; organ morphogenesis; organ regeneration; positive regulation of cellular extravasation; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of leukocyte mediated cytotoxicity; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of synaptic transmission; positive regulation of T cell activation; positive regulation of tumor necrosis factor production; protein amino acid phosphorylation; protein kinase B signaling cascade; regulation of cell shape; response to activity; response to amino acid stimulus; response to antibiotic; response to bacterium; response to ethanol; response to gamma radiation; response to heat; response to hypoxia; response to mechanical stimulus; response to progesterone stimulus; response to vitamin B3; response to wounding; signal transduction; transforming growth factor beta receptor signaling pathway; unfolded protein response; vascular endothelial growth factor receptor signaling pathway; viral genome replication

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To; Neural Tube Defects