Mitogen-Activated Protein Kinase Kinase Kinase (MAP3K1) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

MEKK1: a protein kinase of the STE11 family. Phosphorylates and activates MKK4 and -7, which in turn activate JNK1, -2 and -3. Contains 1 RING-type zinc finger. The RING finger domain of MEKK1 exhibits E3 ubiquitin ligase activity toward c-Jun. c-Jun is downregulated in response to osmotic stress via ubiquitination-mediated degradation by the RING finger domain of MEKK1. Overexpressed/overactivated in multiple tumor types. The Mek1/2 inhibitor U0126 blocks export of influenza viral particles and has been suggested as an antiviral treatment. Single mutations at the same point of each gene also associated with cardiofaciocutaneous syndrome, (also linked with Braf and Kras mutations), displaying morphological, cardiac and mental defects. Inhibitors: U0126, CI-1040/PD184352, PD-0325901 (Phase I cancer), ARRY-142886 (Phase 1, cancer).

Protein type: Protein kinase, STE; EC 2.7.11.25; Ubiquitin ligase; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Ligase; Ubiquitin conjugating system; STE group; STE11 family

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cytoplasm; cytosol; filamentous actin

Molecular Function: ATP binding; cytoskeletal protein binding; JUN kinase kinase kinase activity; MAP kinase kinase kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; zinc ion binding

Biological Process: activation of JNK activity; activation of JNKK activity; activation of protein kinase activity; apoptotic mitochondrial changes; innate immune response; morphogenesis of an epithelial sheet; MyD88-dependent toll-like receptor signaling pathway; positive regulation of actin filament polymerization; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell migration; regulation of mitotic cell cycle; stress-activated protein kinase signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transforming growth factor beta receptor signaling pathway; wound healing

Disease: 46,xy Sex Reversal 6