Stromal Cell-Derived Factor 1 (CXCL12) Mouse Recombinant Protein

Choattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.

Signal sequence trap a cloning strategy for secreted proteins and type I membrane proteins.Tashiro K., Tada H., Heilker R., Shirozu M., Nakano T., Honjo T.Science 261:600-603(1993) Molecular cloning of TPAR1, a gene whose expression is repressed by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) .Jiang W., Zhou P., Kahn S.M., Tomita N., Johnson M.D., Weinstein I.B.Exp. Cell Res. 215:284-293(1994) Molecular cloning and structure of a pre-B-cell growth-stimulating factor.Nagasawa T., Kikutani H., Kishimoto T.Proc. Natl. Acad. Sci. U.S.A. 91:2305-2309(1994) Nomura M., Nakata Y., Uzawa A., Nose M., Akashi M., Suzuki G. Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201) .Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1.Nagasawa T., Hirota S., Tachibana K., Takakura N., Nishikawa S., Kitamura Y., Yoshida N., Kikutani H., Kishimoto T.Nature 382:635-638(1996)

Small volumes of Cxcl12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1265092 is a recombinant protein targeting Cxcl12. Also known as Recombinant Mouse Stromal cell-derived factor 1 protein. Host: E Coli.