Cathepsin K (CTSK) Human Recombinant Protein

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.Shi G.-P., Chapman H.A., Bhairi S.M., Deleeuw C., Reddy V.Y., Weiss S.J.FEBS Lett. 357:129-134(1995) Molecular cloning of human cDNA for cathepsin K novel cysteine proteinase predominantly expressed in bone.Inaoka T., Bilbe G., Ishibashi O., Tezuka K., Kumegawa M., Kokubo T.Biochem. Biophys. Res. Commun. 206:89-96(1995) Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas.Li Y., Alexander M., Wucherpfennig A.L., Yelick P., Chen W., Stashenko P.J. Bone Miner. Res. 10:1197-1202(1995) Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution.Broemme D., Okamoto K.Biol. Chem. Hoppe-Seyler 376:379-384(1995) Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Crystal structure of human cathepsin K complexed with a potent inhibitor.McGrath M.E., Klaus J.L., Barnes M.G., Bromme D.Nat. Struct. Biol. 4:105-109(1997) Design of potent and selective human cathepsin K inhibitors that span the active site.Thompson S.K., Halbert S.M., Bossard M.J., Tomaszek T.A., Levy M.A., Zhao B., Smith W.W., Abdel-Meguid S.S., Janson C.A., D'Alessio K.J., McQueney M.S., Amegadzie B.Y., Hanning C.R., Desjarlais R.L., Briand J., Sarkar S.K., Huddleston M.J., Ijames C.F., Carr S.A., Garnes K.T., Shu A., Heys J.R., Bradbeer J., Zembryki D., Veber D.F.Proc. Natl. Acad. Sci. U.S.A. 94:14249-14254(1997) The crystal structure of human procathepsin K.LaLonde J.M., Zhao B., Janson C.A., D'Alessio K.J., McQueney M.S., Orsini M.J., Debouck C.M., Smith W.W.Biochemistry 38:862-869(1999) Crystal structure of wild-type human procathepsin K.Sivaraman J., Lalumiere M., Menard R., Cygler M.Protein Sci. 8:283-290(1999) Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.Gelb B.D., Shi G.-P., Chapman H.A., Desnick R.J.Science 273:1236-1238(1996) Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis.Gelb B.D., Willner J.P., Dunn T.M., Kardon N.B., Verloes A., Poncin J., Desnick R.J.Am. J. Hum. Genet. 62:848-854(1998) Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein.Ho N., Punturieri A., Wilkin D., Szabo J., Johnson M., Whaley J., Davis J., Clark A., Weiss S., Francomano C.J. Bone Miner. Res. 14:1649-1653(1999) Cathepsin K gene mutations and 1q21 haplotypes in at patients with pycnodysostosis in an outbred population.Haagerup A., Hertz J.M., Christensen M.F., Binderup H., Kruse T.A.Eur. J. Hum. Genet. 8:431-436(2000)

Small volumes of CTSK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS957808 is a recombinant protein targeting CTSK. Also known as Recombinant Human Cathepsin K (CTSK). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.