Vasopressin V1a Receptor (AVPR1A) Rat Recombinant Protein

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social mory formation.

Molecular cloning and expression of a rat V1a arginine vasopressin receptor.Morel A., O'Carroll A.-M., Brownstein M.J., Lolait S.J.Nature 356:523-526(1992) Homology between neurohypophyseal hormone receptors.Wheatley M., Howl J., Morel A., Davis A.R.L.Biochem. J. 296:519-519(1993) Sequence identity between the rat and human vasopressin V1a receptors.Innamorati G., Lolait S.J., Birnbaumer M.Biochem. J. 314:710-711(1996) Molecular cloning and expression of rat V1a and V2 arginine vasopressin receptors.Morel A., Lolait S.J., Brownstein M.J.Regul. Pept. 45:53-59(1993) Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor.Chini B., Mouillac B., Ala Y., Balestre M.-N., Trumpp-Kallmeyer S., Hoflack J., Elands J., Hibert M., Manning M., Jard S., Barberis C.EMBO J. 14:2176-2182(1995) Localization of V1a vasopressin receptor mRNA expression in cultured neurons, astroglia, and oligodendroglia of rat cerebral cortex.Yamazaki R.S., Chen Q., Schreiber S.S., Brinton R.D.Brain Res. Mol. Brain Res. 45:138-140(1997) Effect of N-glycosylation on ligand binding affinity of rat V1a vasopressin receptor.Lee K.-H., Ahn J., Yu D.-H., Jeong H.-S., Lee S.-H., Kim K.-S., Chung I.-Y., Kim J.-H., Lee Y.-S.Biochem. Biophys. Res. Commun. 286:707-713(2001) Palmitoylation of the vasopressin V1a receptor reveals different conformational requirements for signaling, agonist-induced receptor phosphorylation, and sequestration.Hawtin S.R., Tobin A.B., Patel S., Wheatley M.J. Biol. Chem. 276:38139-38146(2001) Immunocytochemical localization of vasopressin v1a receptors in the rat pituitary gonadotropes.Orcel H., Tobin V.A., Alonso G., Rabie A.Endocrinology 143:4385-4388(2002) Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum improved social discrimination and active social behaviour.Landgraf R., Frank E., Aldag J.M., Neumann I.D., Sharer C.A., Ren X., Terwilliger E.F., Niwa M., Wigger A., Young L.J.Eur. J. Neurosci. 18:403-411(2003)

Small volumes of Avpr1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1265325 is a recombinant protein targeting Avpr1a. Also known as Recombinant Rat Vasopressin V1a receptor. Host: E Coli.