Human CSF3 Recombinant Protein – Cat# MBS1265329

Granulocyte Colony-Stimulating Factor (CSF3) Human Recombinant Protein

Name: CSF3 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1265329
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265329

MBS1265329 is a recombinant protein targeting CSF3. Also known as Recombinant Human Granulocyte colony-stimulating factor (CSF3), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Granulocyte colony-stimulating factor (CSF3), Recombinant Protein

Full Product Name

Recombinant Human Granulocyte colony-stimulating factor (CSF3), partial

Product Gene Name

CSF3 recombinant protein

Product Synonym Names

Colony-stimulating factor ; CSFMolgramostin; Sargramostim

Sequence

VQEATPLGPA SSLPQSFLLK CLEQVRKIQG DGAALQEKLV SECATYKLCH PEELVLLGHS LGIPWAPLSS CPSQALQLAG CLSQLHSGLF LYQGLLQALE GISPELGPTL DTLQLDVADF ATTIWQQMEE LGMAPALQPT QGAMPAFASA FQRRAGGVLV ASHLQSFLEV SYRV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

22,293 Da

Sequence Positions

27-200aa, Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 17; NC_000017.10 (38171614..38174066). Location: 17q11.2-q12

OMIM

138970

3D Structure

ModBase 3D Structure for P09919

Species

Homo sapiens (Human)

Subcellular Location

Secreted

Protein Families

IL-6 superfamily

Pathway

Jak-STAT signaling pathway

Relevance

Cytokine that stimulates the growth and differentiation of hatopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Product Categories/Family for CSF3 recombinant protein

Immunology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for CSF3 recombinant protein

SeattleSNPs variation discovery resourceThe DNA sequence and comparative analysis of human chromosome 5.Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.Nature 431:268-274(2004)
https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:2438
https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=2233
https://www.genome.jp/dbget-bin/www_bget?hsa:1440
https://string-db.org/network/9606.ENSP00000225474
https://www.omim.org/entry/138970138970138970

Other Notes

Small volumes of CSF3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CSF3. It may not necessarily be applicable to this product.

NCBI GI #

296011057

NCBI GeneID

1440

NCBI Accession #

NP_001171618.1

UniProt Primary Accession #

P09919

UniProt Secondary Accession #

A8MXR7

UniProt Related Accession #

P09919

GenBank Nucleotide #

NM_001178147.1

NCBI Official Full Name

granulocyte colony-stimulating factor isoform d

NCBI Official Synonym Full Names

colony stimulating factor 3 (granulocyte)

NCBI Official Symbol

CSF3

NCBI Official Synonym Symbols

GCSF; CSF3OS; C17orf33

UniProt Protein Name

Granulocyte colony-stimulating factor

UniProt Synonym Protein Names

Pluripoietin

Protein Family

Granulocyte colony-stimulating factor

UniProt Gene Name

CSF3

UniProt Synonym Gene Names

C17orf33; GCSF; G-CSF

UniProt Entry Name

CSF3_HUMAN

NCBI Protein Information

granulocyte colony-stimulating factor; filgrastim; lenograstim; pluripoietin

NCBI Summary for CSF3

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

UniProt Comments for CSF3

G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cell cycle regulation; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space

Molecular Function: enzyme binding; growth factor activity; cytokine activity; granulocyte colony-stimulating factor receptor binding

Biological Process: granulocyte differentiation; positive regulation of myeloid cell differentiation; positive regulation of protein binding; multicellular organismal development; cytokine and chemokine mediated signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; immune response; positive regulation of transcription from RNA polymerase II promoter

Research Articles on CSF3

1. Administration of G-CSF in a dosage regimen commonly used for bone marrow donors is well tolerated and safe, and provides a signal of positive change in a task of cognitive performance in 8 patients with mild to moderate stage Alzheimer's disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CSF3 recombinant protein

Reference Product	PubMed Publications
CSF2 recombinant protein	>14 publications with CSF3 and CSF2
CSF3R recombinant protein	>11 publications with CSF3 and CSF3R
MMP9 recombinant protein	>5 publications with CSF3 and MMP9
IL10 recombinant protein	>4 publications with CSF3 and IL10
CXCL12 recombinant protein	>3 publications with CSF3 and CXCL12
SELL recombinant protein	>1 publications with CSF3 and SELL
STAT3 recombinant protein	>1 publications with CSF3 and STAT3
CXCR4 recombinant protein	>1 publications with CSF3 and CXCR4

Pathways associated with CSF3 recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with CSF3 recombinant protein

Disease Name	Pubmed Publications
Disease Susceptibility Antibodies	>6 publications with CSF3 and Disease Susceptibility
Nervous System Diseases Antibodies	>4 publications with CSF3 and Nervous System Diseases
Neutropenia Antibodies	>3 publications with CSF3 and Neutropenia
Leukopenia Antibodies	>2 publications with CSF3 and Leukopenia
Anemia Antibodies	>2 publications with CSF3 and Anemia
Leukemia, Myeloid, Acute Antibodies	>2 publications with CSF3 and Leukemia, Myeloid, Acute
Breast Neoplasms Antibodies	>1 publications with CSF3 and Breast Neoplasms
Peripheral Nervous System Diseases Antibodies	>1 publications with CSF3 and Peripheral Nervous System Diseases
Pulmonary Fibrosis Antibodies	>1 publications with CSF3 and Pulmonary Fibrosis
Brain Injuries Antibodies	>1 publications with CSF3 and Brain Injuries

Organs/Tissues associated with CSF3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>5 publications with CSF3 and Skin
Lung Antibodies	>3 publications with CSF3 and Lung
Muscle Antibodies	>2 publications with CSF3 and Muscle
Liver Antibodies	>1 publications with CSF3 and Liver
Brain Antibodies	>1 publications with CSF3 and Brain
Uterus Antibodies	>1 publications with CSF3 and Uterus
Uncharacterized Tissue Antibodies	>1 publications with CSF3 and Uncharacterized Tissue