Human SPEG Recombinant Protein – Cat# MBS1265360

Striated Muscle Preferentially Expressed Protein Kinase (SPEG) Human Recombinant Protein

Name: SPEG Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1265360
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265360

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Striated muscle preferentially expressed protein kinase (SPEG), Recombinant Protein

Full Product Name

Recombinant Human Striated muscle preferentially expressed protein kinase

Product Gene Name

SPEG recombinant protein

Product Synonym Names

Aortic preferentially expressed protein 1; APEG-1

Sequence

MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGGGAPVAVA GAPVFLRPLK NAAVCAGSDV RLRVVVSGTP QPSLRWFRDG QLLPAPAPEP SCLWLRRCGA QDAGVYSCMA QNE

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

38.7 kDa

Sequence Positions

1-113aa; Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

615950

3D Structure

ModBase 3D Structure for Q15772

Product Categories/Family for SPEG recombinant protein

Developmental Biology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for SPEG recombinant protein

APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury.Hsieh C.-M., Yoshizumi M., Endege W.O., Kho C.-J., Jain M.K., Kashiki S., de Los Santos R., Lee W.-S., Perrella M.A., Lee M.-E.J. Biol. Chem. 271:17354-17359(1996)

Other Notes

Small volumes of SPEG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPEG purchase

MBS1265360 is a recombinant protein targeting SPEG. Also known as Recombinant Human Striated muscle preferentially expressed protein kinase. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SPEG. It may not necessarily be applicable to this product.

NCBI GI #

291042650

NCBI GeneID

10290

NCBI Accession #

NP_001166947.1

UniProt Primary Accession #

Q15772

UniProt Secondary Accession #

Q27J74; Q695L1; Q6FGA6; Q6ZQW1; Q6ZTL8; Q9P2P9; A8K0G6; A8MRU0

UniProt Related Accession #

Q15772

GenBank Nucleotide #

NM_001173476.1

NCBI Official Full Name

striated muscle preferentially expressed protein kinase isoform 4

NCBI Official Synonym Full Names

SPEG complex locus

NCBI Official Symbol

SPEG

NCBI Official Synonym Symbols

BPEG; CNM5; APEG1; APEG-1; SPEGbeta; SPEGalpha

UniProt Protein Name

Striated muscle preferentially expressed protein kinase

UniProt Synonym Protein Names

Aortic preferentially expressed protein 1; APEG-1

Protein Family

Exotoxin

UniProt Gene Name

SPEG

UniProt Synonym Gene Names

APEG1; KIAA1297; APEG-1

UniProt Entry Name

SPEG_HUMAN

NCBI Protein Information

striated muscle preferentially expressed protein kinase

NCBI Summary for SPEG

This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined. [provided by RefSeq, Mar 2010]

UniProt Comments for SPEG

SPEG: Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 4 isoforms of the human protein are produced by alternative promoter.

Protein type: Protein kinase, CAMK; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; Trio family

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: nucleus

Molecular Function: ATP binding; protein binding; protein serine/threonine kinase activity

Biological Process: cardiac muscle cell development; in utero embryonic development; muscle development; negative regulation of cell proliferation; protein amino acid phosphorylation

Disease: Myopathy, Centronuclear, 5

Research Articles on SPEG

1. SPEG is present in cardiac muscle, where it plays a critical role; therefore, individuals with SPEG mutations additionally present with dilated cardiomyopathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SPEG recombinant protein

Reference Product	PubMed Publications
DES recombinant protein	>4 publications with SPEG and DES

Diseases associated with SPEG recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>11 publications with SPEG and Inflammation
Cardiovascular Diseases Antibodies	>6 publications with SPEG and Cardiovascular Diseases
Heart Diseases Antibodies	>5 publications with SPEG and Heart Diseases
Nervous System Diseases Antibodies	>3 publications with SPEG and Nervous System Diseases
Diabetes Mellitus Antibodies	>3 publications with SPEG and Diabetes Mellitus
Cardiomegaly Antibodies	>2 publications with SPEG and Cardiomegaly
Lung Diseases Antibodies	>1 publications with SPEG and Lung Diseases
Disease Models, Animal Antibodies	>1 publications with SPEG and Disease Models, Animal
Memory Disorders Antibodies	>1 publications with SPEG and Memory Disorders
Liver Diseases Antibodies	>1 publications with SPEG and Liver Diseases

Organs/Tissues associated with SPEG recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>13 publications with SPEG and Blood
Muscle Antibodies	>12 publications with SPEG and Muscle
Skin Antibodies	>10 publications with SPEG and Skin
Heart Antibodies	>7 publications with SPEG and Heart
Nerve Antibodies	>4 publications with SPEG and Nerve
Ganglia Antibodies	>3 publications with SPEG and Ganglia
Ovary Antibodies	>2 publications with SPEG and Ovary
Connective Tissue Antibodies	>2 publications with SPEG and Connective Tissue
Embryonic Tissue Antibodies	>2 publications with SPEG and Embryonic Tissue
Lung Antibodies	>1 publications with SPEG and Lung