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mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles.Gekeler V., Weger S., Probst H.Biochem. Biophys. Res. Commun. 169:796-802(1990)
P-glycoprotein gene (MDR1)
cDNA from human adrenal
normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.Kioka N., Tsubota J., Kakehi Y., Komano T., Gottesman M.M., Pastan I., Ueda K.Biochem. Biophys. Res. Commun. 162:224-231(1989)
ABC drug transporters
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Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.Begley G.S., Horvath A.R., Taylor J.C., Higgins C.F.Mol. Immunol. 42:137-141(2005)
A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008)
Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011)
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An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein)
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Genetic polymorphism in MDR-1
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A new polymorphism (N21D)
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Functional polymorphisms of the human multidrug-resistance gene
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Polymorphism of MDR1 gene in healthy Japanese subjects
a novel SNP with an amino acid substitution (Glu108Lys)
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Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone.Itoda M., Saito Y., Komamura K., Ueno K., Kamakura S., Ozawa S., Sawada J.Drug Metab. Pharmacokinet. 17:566-571(2002)
Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP)
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MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.Brant S.R., Panhuysen C.I.M., Nicolae D., Reddy D.M., Bonen D.K., Karaliukas R., Zhang L., Swanson E., Datta L.W., Moran T., Ravenhill G., Duerr R.H., Achkar J.-P., Karban A.S., Cho J.H.Am. J. Hum. Genet. 73:1282-1292(2003)
ErratumBrant S.R., Panhuysen C.I.M., Nicolae D., Reddy D.M., Bonen D.K., Karaliukas R., Zhang L., Swanson E., Datta L.W., Moran T., Ravenhill G., Duerr R.H., Achkar J.-P., Karban A.S., Cho J.H.Am. J. Hum. Genet. 74:1080-1080(2004)
The consensus coding sequences of human breast and colorectal cancers.Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.Science 314:268-274(2006)
+Additional computationally mapped references.<p>Provides general information on the entry.