Actin, Cytoplasmic 1 Protein (ACTB) Human Recombinant Protein

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Evolutionary conservation in the untranslated regions of actin mRNAs DNA sequence of a human beta-actin cDNA.Ponte P., Ng S.Y., Engel J., Gunning P., Kedes L.Nucleic Acids Res. 12:1687-1696(1984) Molecular structure of the human cytoplasmic beta-actin gene interspecies homology of sequences in the introns.Nakajima-Iijima S., Hamada H., Reddy P., Kakunaga T.Proc. Natl. Acad. Sci. U.S.A. 82:6133-6137(1985) Direct proof that the primary site of action of cytochalasin on cell motility processes is actin.Ohmori H., Toyama S., Toyama S.J. Cell Biol. 116:933-941(1992) NIEHS SNPs programThe DNA sequence of human chromosome 7.Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.Nature 424:157-164(2003) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.Nat. Biotechnol. 21:566-569(2003) Bienvenut W.V.Submitted (JUN-2005) to UniProtKB Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.Submitted (DEC-2008) to UniProtKB Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions.Hanukoglu I., Tanese N., Fuchs E.J. Mol. Biol. 163:673-678(1983) Exportin 6 a novel nuclear export receptor that is specific for profilin.actin complexes.Stueven T., Hartmann E., Goerlich D.EMBO J. 22:5928-5940(2003) Emerin caps the pointed end of actin filaments evidence for an actin cortical network at the nuclear inner membrane.Holaska J.M., Kowalski A.K., Wilson K.L.PLoS Biol. 2:1354-1362(2004) Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.Giannakopoulos N.V., Luo J.K., Papov V., Zou W., Lenschow D.J., Jacobs B.S., Borden E.C., Li J., Virgin H.W., Zhang D.E.Biochem. Biophys. Res. Commun. 336:496-506(2005) HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration.Lu X., Chen J., Malumbres R., Cubedo Gil E., Helfman D.M., Lossos I.S.Blood 110:4268-4277(2007) Molecular composition of IMP1 ribonucleoprotein granules.Joeson L., Vikesaa J., Krogh A., Nielsen L.K., Hansen T., Borup R., Johnsen A.H., Christiansen J., Nielsen F.C.Mol. Cell. Proteomics 6:798-811(2007) Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.Lange M., Kaynak B., Forster U.B., Toenjes M., Fischer J.J., Grimm C., Schlesinger J., Just S., Dunkel I., Krueger T., Mebus S., Lehrach H., Lurz R., Gobom J., Rottbauer W., Abdelilah-Seyfried S., Sperling S.Genes Dev. 22:2370-2384(2008) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C.Cancer Res. 71:4269-4279(2011) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.Procaccio V., Salazar G., Ono S., Styers M.L., Gearing M., Davila A., Jimenez R., Juncos J., Gutekunst C.-A., Meroni G., Fontanella B., Sontag E., Sontag J.-M., Faundez V., Wainer B.H.Am. J. Hum. Genet. 78:947-960(2006) GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.Fujiki R., Chikanishi T., Hashiba W., Ito H., Takada I., Roeder R.G., Kitagawa H., Kato S.Nature 459:455-459(2009) ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.Li M.M., Nilsen A., Shi Y., Fusser M., Ding Y.H., Fu Y., Liu B., Niu Y., Wu Y.S., Huang C.M., Olofsson M., Jin K.X., Lv Y., Xu X.Z., He C., Dong M.Q., Rendtlew Danielsen J.M., Klungland A., Yang Y.G.Nat. Commun. 4:1832-1832(2013) De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.Riviere J.B., van Bon B.W., Hoischen A., Kholmanskikh S.S., O'Roak B.J., Gilissen C., Gijsen S., Sullivan C.T., Christian S.L., Abdul-Rahman O.A., Atkin J.F., Chassaing N., Drouin-Garraud V., Fry A.E., Fryns J.P., Gripp K.W., Kempers M., Kleefstra T., Mancini G.M., Nowaczyk M.J., van Ravenswaaij-Arts C.M., Roscioli T., Marble M., Rosenfeld J.A., Siu V.M., de Vries B.B., Shendure J., Verloes A., Veltman J.A., Brunner H.G., Ross M.E., Pilz D.T., Dobyns W.B.Nat. Genet. 44:440-444(2012)

Small volumes of ACTB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1265534 is a recombinant protein targeting ACTB. Also known as Recombinant Human Actin, cytoplasmic 1 protein. Host: E Coli.