• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Haptoglobin Protein (HP) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265546

As a result of holysis, hoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hoglobin to allow hepatic recycling of he iron and to prevent kidney damage. Haptoglobin also acts as an… More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Haptoglobin protein (HP), Recombinant Protein
Full Product Name
Recombinant Rat Haptoglobin protein
Product Gene Name
HP recombinant protein
Product Synonym Names
Liver regeneration-related protein LRRG173; Zonulin
Sequence
VELGNDATDI EDDSCPKPPE IANGYVEHLV RYRCRQFYKL QTEGDGIYTL NSEKQWVNPA AGDKLPKCEA VCGKPKHPVD QVQRIIGGSM DAKGSFPWQA KMISRHGLTT GATLISDQWL LTTAQNLFLN HSENATAKDI APTLTLYVGK NQLVEIEKVV LHPERSVVDI GLIKLKQKVL VTEKVMPICL PSKDYVAPGR MGYVSGWGRN VNFRFTERLK YVMLPVADQE KCELHYEKST VPEKKGAVSP VGVQPILNKH TFCAGLTKYE EDTCYGDAGS AFAVHDTEED TWYAAGILSF DKSCAVAEYG VYVRATDLKD WVQETMAK
Host
E Coli
Form/Format
Liquid containing glycerol
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
40.5 kDa
Sequence Positions
19-346aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P06866

Product Categories/Family for HP recombinant protein

Epigenetics and Nuclear Signaling
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of HP recombinant protein

Rat HP Recombinant Protein – Cat# MBS1265546

Product References and Citations for HP recombinant protein

Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene.Marinkovic S., Baumann H.Mol. Cell. Biol. 10:1573-1583(1990) Liver regeneration after PH.Xu C.S., Li W.Q., Li Y.C., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Shi J.B., Rahman S., Wang Q.N., Zhang J.B. Nucleotide sequence of rat haptoglobin cDNA. Characterization of the alpha beta-subunit junction region of prohaptoglobin.Goldstein L.A., Heath E.C.J. Biol. Chem. 259:9212-9217(1984) Biosynthesis and processing of rat haptoglobin.Hanley J.M., Haugen T.H., Heath E.C.J. Biol. Chem. 258:7858-7869(1983) Comparative sequence analysis of the N-terminal region of rat, rabbit, and dog haptoglobin beta-chains.Kurosky A., Kim H.H., Touchstone B.Comp. Biochem. Physiol. 55B:453-459(1976) Lubec G., Afjehi-Sadat L.Submitted (DEC-2006) to UniProtKB

Other Notes

Small volumes of HP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HP purchase

MBS1265546 is a recombinant protein targeting HP. Also known as Recombinant Rat Haptoglobin protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HP. It may not necessarily be applicable to this product.

NCBI GI #
60097941
NCBI GeneID
24464
NCBI Accession #
NP_036714.2
UniProt Primary Accession #
P06866
UniProt Secondary Accession #
Q5EBB4; Q7TP23
UniProt Related Accession #
P06866
GenBank Nucleotide #
NM_012582.2
NCBI Official Full Name
haptoglobin
NCBI Official Synonym Full Names
haptoglobin
NCBI Official Symbol
Hp
NCBI Official Synonym Symbols
Ba1-647
UniProt Protein Name
Haptoglobin
UniProt Synonym Protein Names
Liver regeneration-related protein LRRG173; Zonulin
UniProt Gene Name
Hp
UniProt Entry Name
HPT_RAT
NCBI Protein Information
haptoglobin

NCBI Summary for HP

may bind hemoglobin and mediate hemoglobin catabolism in lung cells; may play a role in inflammatory response [RGD, Feb 2006]

UniProt Comments for HP

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.

Protein type: Enzyme, misc.; Protease; Endoplasmic reticulum; Secreted, signal peptide; Secreted

Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus

Molecular Function: antioxidant activity; hemoglobin binding; protein homodimerization activity; serine-type endopeptidase activity

Biological Process: acute inflammatory response; acute-phase response; defense response to bacterium; immune system process; liver development; negative regulation of oxidoreductase activity; Notch signaling pathway; organ regeneration; proteolysis; response to cobalamin; response to drug; response to electrical stimulus; response to glucocorticoid stimulus; response to heat; response to hydrogen peroxide; response to hypoxia; response to L-ascorbic acid; response to lead ion; response to lipopolysaccharide; response to magnesium ion; response to organic cyclic substance; response to organic substance; response to X-ray; spermatogenesis
Show more

Research Articles on HP

1. This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HP recombinant protein

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with HP recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1827 publications with HP and Cardiovascular Diseases
 Inflammation Antibodies  >1300 publications with HP and Inflammation
 Hypersensitivity Antibodies  >701 publications with HP and Hypersensitivity
 Hypertension Antibodies  >563 publications with HP and Hypertension
 Autoimmune Diseases Antibodies  >548 publications with HP and Autoimmune Diseases
 Kidney Diseases Antibodies  >521 publications with HP and Kidney Diseases
 Necrosis Antibodies  >520 publications with HP and Necrosis
 Fibrosis Antibodies  >508 publications with HP and Fibrosis
 Arthritis Antibodies  >359 publications with HP and Arthritis
 Leukemia Antibodies  >317 publications with HP and Leukemia

Organs/Tissues associated with HP recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1374 publications with HP and Liver
 Lung Antibodies  >1290 publications with HP and Lung
 Connective Tissue Antibodies  >356 publications with HP and Connective Tissue
 Spleen Antibodies  >158 publications with HP and Spleen
 Uncharacterized Tissue Antibodies  >1 publications with HP and Uncharacterized Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000