Calcitonin Gene-Related Peptide 1 (CALCA) Human Recombinant Protein

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.

Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W., Mermod J.-J., Evans R.M., Rosenfeld M.G.Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985) Structure and methylation of the human calcitonin/alpha-CGRP gene.Broad P.M., Symes A.J., Thakker R.V., Craig R.K.Nucleic Acids Res. 17:6999-7011(1989) Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006) Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.Nelkin B.D., Rosenfeld K.I., de Bustros A., Leong S.S., Roos B.A., Baylin S.B.Biochem. Biophys. Res. Commun. 123:648-655(1984) Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma.Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D., Pettengill O.S., Craig R.K.EMBO J. 4:715-724(1985) Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma.Steenbergh P.H., Hoppener J.W., Zandberg J., de Ven W.J., Jansz H.S., Lips C.J.J. Clin. Endocrinol. Metab. 59:358-360(1984) Expression and function of the human calcitonin/alpha-CGRP gene in health and disease.Craig R.K., Riley J.H., Edbrooke M.R., Broad P.M., Foord S.M., Al-Kazwini S.J., Holman J.J., Marshall I.Biochem. Soc. Symp. 52:91-105(1986) Isolation and characterization of human calcitonin gene-related peptide.Morris H.R., Panico M., Etienne T., Tippins J., Girgis S.I., McIntyre I.Nature 308:746-748(1984) Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord.Petermann J.B., Born W., Chang J.Y., Fischer J.A.J. Biol. Chem. 262:542-545(1987) Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.Biochem. Biophys. Res. Commun. 185:134-141(1992) Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.Breeze A.L., Harvey T.S., Bazzo R., Campbell I.D.Biochemistry 30:575-582(1991) Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin.Hubbard J.A.M., Martin S.R., Chaplin L.C., Bose C., Kelly S.M., Price N.C.Biochem. J. 275:785-788(1991)

Small volumes of CALCA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1265589 is a recombinant protein targeting CALCA. Also known as Recombinant Human Calcitonin gene-related peptide 1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.