Glycoprotein (G) Rabies Virus Recombinant Protein

This rabies virus glycoprotein (G) recombinant protein attaches the virus to the host cell receptor and induces endocytosis of the virion, triggering fusion between the virus and cell membrane.

Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.

Structure of the glycoprotein gene in rabies virus.Anilionis A., Wunner W.H., Curtis P.J.Nature 294:275-278(1981) Amino acid sequence of the rabies virus glycoprotein deduced from its cloned gene.Anilionis A., Wunner W.H., Curtis P.J.Comp. Immunol. Microbiol. Infect. Dis. 5:27-32(1982) Complete nucleotide sequencing of SAD derivatives of attenuated rabies virus vaccine strains.Geue L., Schares S., Schnick C., Kliemt J., Beckert A., Hoffmann B., Freuling C., Marston D., McElhinney L., Fooks A., Zanoni R., Peterhans E., Cox J.H., Mueller T. Antigenic variants of CVS rabies virus with altered glycosylation sites.Wunner W.H., Dietzschold B., Smith C.L., Lafon M., Golub E.Virology 140:1-12(1985) N-linked glycosylation of rabies virus glycoprotein. Individual sequons differ in their glycosylation efficiencies and influence on cell surface expression.Shakin-Eshleman S.H., Remaley A.T., Eshleman J.R., Wunner W.H., Spitalnik S.L.J. Biol. Chem. 267:10690-10698(1992) The role of site-specific N-glycosylation in secretion of soluble forms of rabies virus glycoprotein.Wojczyk B.S., Stwora-Wojczyk M., Shakin-Eshleman S.H., Wunner W.H., Spitalnik S.L.Glycobiology 8:121-130(1998) Rabies virus receptors.Lafon M.J. Neurovirol. 11:82-87(2005)

Small volumes of G recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1265619 is a recombinant protein targeting G. Also known as Recombinant Rabies virus Glycoprotein (G), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.