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TDGF1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS126607
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Cripto, also known as teratocarcinoma derived growth factor 1 (TDGF-1), belongs to the EGF-CFC family of proteins. Members of this family are characterized by an N-terminal signal peptide, a conserved cysteine rich domain (CFC motif), and a short hydrophobic… More details

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Product Overview

Online Datasheet in PDF
Product Name
TDGF1, Polyclonal Antibody
Full Product Name
TDGF1 Polyclonal Antibody
Product Gene Name
anti-TDGF1 antibody
Product Synonym Names
TDGF1; CR; CRGF; CRIPTO; Cripto-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
188
OMIM
187395
3D Structure
ModBase 3D Structure for P13385
Species
Human
Immunogen
Recombinant protein of human TDGF1
Calculated Molecular Weight
21kDa

Product Categories/Family for anti-TDGF1 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TDGF1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TDGF1 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western Blot (WB) of anti-TDGF1 antibody

Western blot analysis of extracts of HepG2 cells, using TDGF1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
Rabbit Anti-TDGF1 Polyclonal Antibody – Cat# MBS126607

Immunohistochemistry (IHC) of anti-TDGF1 antibody

Immunohistochemistry of paraffin-embedded mouse kidney using TDGF1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-TDGF1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS126607

Immunohistochemistry (IHC) of anti-TDGF1 antibody

Immunohistochemistry of paraffin-embedded rat kidney using TDGF1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-TDGF1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS126607

Immunohistochemistry (IHC) of anti-TDGF1 antibody

Immunohistochemistry of paraffin-embedded human stomach using TDGF1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-TDGF1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS126607

Other Notes

Small volumes of anti-TDGF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TDGF1 purchase

MBS126607 is an antibody targeting TDGF1. Also known as TDGF1 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TDGF1. It may not necessarily be applicable to this product.

NCBI GI #
117473
NCBI GeneID
6997
NCBI Accession #
P13385.1
UniProt Primary Accession #
P13385
UniProt Secondary Accession #
Q8TCC1
UniProt Related Accession #
P13385
NCBI Official Full Name
Teratocarcinoma-derived growth factor 1
NCBI Official Synonym Full Names
teratocarcinoma-derived growth factor 1
NCBI Official Symbol
TDGF1
NCBI Official Synonym Symbols
CR; CRGF; CRIPTO
UniProt Protein Name
Teratocarcinoma-derived growth factor 1
UniProt Synonym Protein Names
Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1
Protein Family
Teratocarcinoma-derived growth factor
UniProt Gene Name
TDGF1
UniProt Synonym Gene Names
CRIPTO; CRGF
UniProt Entry Name
TDGF1_HUMAN
NCBI Protein Information
teratocarcinoma-derived growth factor 1; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1

NCBI Summary for TDGF1

This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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UniProt Comments for TDGF1

TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Protein type: Motility/polarity/chemotaxis; Cell cycle regulation; Membrane protein, GPI anchor; Membrane protein, peripheral; Cell adhesion

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: extrinsic to plasma membrane; Golgi apparatus; extracellular space; cell surface; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; nucleus; lipid raft

Molecular Function: protein binding; growth factor activity; receptor binding

Biological Process: somatic stem cell maintenance; activation of MAPK activity; heart development; regulation of signal transduction; gastrulation; Wnt receptor signaling pathway through beta-catenin; cardiac muscle cell differentiation; BMP signaling pathway; positive regulation of fibroblast proliferation; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; cell differentiation; vasculogenesis; epidermal growth factor receptor signaling pathway; in utero embryonic development; morphogenesis of a branching structure; peptidyl-serine phosphorylation; embryonic development; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of apoptosis; positive regulation of cell migration
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Research Articles on TDGF1

1. Data suggest that the high expression of Cripto-1 (CR-1) may play an important role in the progression of non-small cell lung cancer (NSCLC), and CR-1 expression may offer a valuable marker for predicting the outcome of patients with NSCLC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TDGF1 antibody

 Reference Product  PubMed Publications
 NODAL antibody  >86 publications with TDGF1 and NODAL
 ACVR1B antibody  >18 publications with TDGF1 and ACVR1B
 ACVR2A antibody  >3 publications with TDGF1 and ACVR2A
 ACVR1C antibody  >3 publications with TDGF1 and ACVR1C
 ACVR2B antibody  >1 publications with TDGF1 and ACVR2B

Pathways associated with anti-TDGF1 antibody

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway antibodies  POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 Transcriptional Regulation Of Pluripotent Stem Cells Pathway antibodies  Transcriptional Regulation Of Pluripotent Stem Cells Pathway Diagram

Diseases associated with anti-TDGF1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >38 publications with TDGF1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >19 publications with TDGF1 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >19 publications with TDGF1 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >12 publications with TDGF1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >12 publications with TDGF1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >11 publications with TDGF1 and Nervous System Diseases
 Holoprosencephaly Antibodies  >9 publications with TDGF1 and Holoprosencephaly
 Uterine Diseases Antibodies  >8 publications with TDGF1 and Uterine Diseases
 Nervous System Malformations Antibodies  >7 publications with TDGF1 and Nervous System Malformations
 Craniofacial Abnormalities Antibodies  >7 publications with TDGF1 and Craniofacial Abnormalities

Organs/Tissues associated with anti-TDGF1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >62 publications with TDGF1 and Embryonic Tissue
 Muscle Antibodies  >23 publications with TDGF1 and Muscle
 Liver Antibodies  >12 publications with TDGF1 and Liver
 Brain Antibodies  >12 publications with TDGF1 and Brain
 Testis Antibodies  >7 publications with TDGF1 and Testis
 Uterus Antibodies  >6 publications with TDGF1 and Uterus
 Kidney Antibodies  >4 publications with TDGF1 and Kidney
 Prostate Antibodies  >4 publications with TDGF1 and Prostate
 Intestine Antibodies  >4 publications with TDGF1 and Intestine
 Spleen Antibodies  >3 publications with TDGF1 and Spleen
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