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TCP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS126767
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The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different… More details

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Technical Datasheet View PDF
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Product Overview

Product Name
TCP1, Polyclonal Antibody
Full Product Name
TCP1 Polyclonal Antibody
Product Gene Name
anti-TCP1 antibody
Product Synonym Names
CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
556
OMIM
186980
3D Structure
ModBase 3D Structure for P17987
Species
Human
Immunogen
Recombinant protein of human TCP1
Calculated Molecular Weight
60kDa

Product Categories/Family for anti-TCP1 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TCP1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TCP1 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Western Blot (WB) of anti-TCP1 antibody

Western blot analysis of extracts of various cell lines, using TCP1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Rabbit Anti-TCP1 Polyclonal Antibody – Cat# MBS126767

Immunohistochemistry (IHC) of anti-TCP1 antibody

Immunohistochemistry of paraffin-embedded rat kidney using TCP1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-TCP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS126767

Immunofluorescence (IF) of anti-TCP1 antibody

Immunofluorescence analysis of U2OS cells using TCP1 antibody. Blue: DAPI for nuclear staining.
Rabbit Anti-TCP1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS126767

Other Notes

Small volumes of anti-TCP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TCP1 purchase

MBS126767 is an antibody targeting TCP1. Also known as TCP1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TCP1. It may not necessarily be applicable to this product.

NCBI GI #
135538
NCBI GeneID
6950
NCBI Accession #
P17987.1
UniProt Primary Accession #
P17987
UniProt Secondary Accession #
Q15556; Q5TCM3; E1P5B2
UniProt Related Accession #
P17987
NCBI Official Full Name
T-complex protein 1 subunit alpha
NCBI Official Synonym Full Names
t-complex 1
NCBI Official Symbol
TCP1
NCBI Official Synonym Symbols
CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha
UniProt Protein Name
T-complex protein 1 subunit alpha
UniProt Synonym Protein Names
CCT-alpha
Protein Family
T-complex protein
UniProt Gene Name
TCP1
UniProt Synonym Gene Names
CCT1; CCTA; TCP-1-alpha
UniProt Entry Name
TCPA_HUMAN
NCBI Protein Information
T-complex protein 1 subunit alpha; tailless complex polypeptide 1; T-complex protein 1, alpha subunit

UniProt Comments for TCP1

CCT-alpha: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Belongs to the TCP-1 chaperonin family.

Protein type: Chaperone; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q25.3-q26

Cellular Component: chaperonin-containing T-complex; Golgi apparatus; centrosome; microtubule; pericentriolar material; acrosome; nuclear heterochromatin; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding

Biological Process: tubulin folding; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; binding of sperm to zona pellucida
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Research Articles on TCP1

1. CCT8 might be an oncogene and participate in HCC cell proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TCP1 antibody

 Reference Product  PubMed Publications
 CCT5 antibody  >102 publications with TCP1 and CCT5
 PPP2CB antibody  >1 publications with TCP1 and PPP2CB
 PPP2CA antibody  >1 publications with TCP1 and PPP2CA

Pathways associated with anti-TCP1 antibody

 Products by Pathway  Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 BBSome-mediated Cargo-targeting To Cilium Pathway antibodies  BBSome-mediated Cargo-targeting To Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies  Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
 Folding Of Actin By CCT/TriC Pathway antibodies  Folding Of Actin By CCT/TriC Pathway Diagram
 Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway antibodies  Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram

Diseases associated with anti-TCP1 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >9 publications with TCP1 and Carcinoma
 Cardiovascular Diseases Antibodies  >5 publications with TCP1 and Cardiovascular Diseases
 Inflammation Antibodies  >5 publications with TCP1 and Inflammation
 Immune System Diseases Antibodies  >5 publications with TCP1 and Immune System Diseases
 Heart Diseases Antibodies  >3 publications with TCP1 and Heart Diseases
 Lung Diseases Antibodies  >3 publications with TCP1 and Lung Diseases
 Lung Neoplasms Antibodies  >3 publications with TCP1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with TCP1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >2 publications with TCP1 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with TCP1 and Liver Neoplasms

Organs/Tissues associated with anti-TCP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with TCP1 and Blood
 Testis Antibodies  >15 publications with TCP1 and Testis
 Brain Antibodies  >11 publications with TCP1 and Brain
 Liver Antibodies  >6 publications with TCP1 and Liver
 Nerve Antibodies  >6 publications with TCP1 and Nerve
 Heart Antibodies  >6 publications with TCP1 and Heart
 Kidney Antibodies  >4 publications with TCP1 and Kidney
 Lung Antibodies  >4 publications with TCP1 and Lung
 Muscle Antibodies  >4 publications with TCP1 and Muscle
 Embryonic Tissue Antibodies  >3 publications with TCP1 and Embryonic Tissue
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