ABCB1 Antibody – Rabbit Polyclonal

MDR1/ABCB1 belongs to the Mdr/Tap subfamily of the ATP binding casette transporter superfamily (1). MDR1 serves as an efflux pump for xenobiotic compounds with broad substrate specificity. Its substrates include therapeutic agents, such as actinomycin D, etoposide, imatinib, and doxorubicin, as well as endogenous molecules, such as betaamyloids, steroid hormones, lipids, phospholipids, cholesterol, and cytokines (2). Research studies have shown that MDR1 reduces drug accumulation in cancer cells, allowing the development of drug resistance (35). On the other hand, MDR1 expressed in the plasma membrane of cells in the bloodbrain, bloodcerebral spinal fluid, or bloodplacenta barriers restricts the permeability of drugs into these organs from the apical or serosal side (6,7). MDR1 is also expressed in normal tissues with excretory function such as small intestine, liver, and kidney (7). Intracellular MDR1 has been detected in the ER, vesicles, and nuclear envelope, and has been associated with cell trafficking machinery (8). Other reported functions of MDR1 include viral resistance, cytokine trafficking (9,10), and lipid homeostasis in the peripheral and central nervous system (1113).

1. Furuya, K.N. et al. (1997) Cancer Res 57, 3708-16 2. Litman, T. et al. (1997) Biochim Biophys Acta 1361, 16976. 3. Chen, C.J. et al. (1986) Cell 47, 3819. 4. Kartner, N. et al. (1983) Cancer Res 43, 44139. 5. Chen, G. et al. (1997) J Biol Chem 272, 597482. 6. Brinkmann, U. and Eichelbaum, M. (2001) Pharmacogenomics J 1, 5964. 7. Fromm, M.F. (2004) Trends Pharmacol Sci 25, 4239. 8. Miller, D.S. et al. (2008) Pharmacol Rev 60, 196209. Ambudkar, S.V. et al. (1999) Annu Rev Pharmacol Toxicol 39, 36198. 10. Raviv, Y. et al. (2000) FASEB J 14, 5115 11. Meijer, O.C. et al. (2003) J Endocrinol 178, 138. 12. Karssen, A.M. et al. (2002) J Endocrinol 175, 25160 13. Jeannesson, E. et al. (2009) Clin Chim Acta 403, 198202.

Small volumes of anti-ABCB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS126773 is an antibody targeting ABCB1. Also known as ABCB1 Polyclonal Antibody. Reactive in Human. Host: Rabbit.