Rabbit Anti-CXCL10 Polyclonal Antibody – Cat# MBS126809

Western blot analysis of extracts of HeLa cells, using CXCL10 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.

CXCL10 Antibody – Rabbit Polyclonal

Name: CXCL10 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS126809
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS126809

This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule… More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CXCL10, Polyclonal Antibody

Full Product Name

CXCL10 Polyclonal Antibody

Product Gene Name

anti-CXCL10 antibody

Product Synonym Names

C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.

Molecular Weight

OMIM

147310

3D Structure

ModBase 3D Structure for P02778

Species

Human

Immunogen

Recombinant protein of human CXCL10

Calculated Molecular Weight

10kDa

Product Categories/Family for anti-CXCL10 antibody

Polyclonal

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-CXCL10 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-CXCL10 antibody

WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Other Notes

Small volumes of anti-CXCL10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL10 purchase

MBS126809 is an antibody targeting CXCL10. Also known as CXCL10 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL10. It may not necessarily be applicable to this product.

NCBI GI #

21542456

NCBI GeneID

3627

NCBI Accession #

P02778.2

UniProt Primary Accession #

P02778

UniProt Secondary Accession #

Q96QJ5

UniProt Related Accession #

P02778

NCBI Official Full Name

C-X-C motif chemokine 10

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 10

NCBI Official Symbol

CXCL10

NCBI Official Synonym Symbols

C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10

UniProt Protein Name

C-X-C motif chemokine 10

UniProt Synonym Protein Names

10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10CXCL10(1-73)

Protein Family

C-X-C motif chemokine

UniProt Gene Name

CXCL10

UniProt Synonym Gene Names

INP10; SCYB10; Gamma-IP10; IP-10

UniProt Entry Name

CXL10_HUMAN

NCBI Protein Information

C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10

NCBI Summary for CXCL10

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

UniProt Comments for CXCL10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding

Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; response to vitamin D; cell surface receptor linked signal transduction; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; immune response; positive regulation of transcription from RNA polymerase II promoter; response to cold; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; regulation of protein kinase activity; negative regulation of myoblast differentiation; defense response to virus

Research Articles on CXCL10

1. We found that heparanase induction is associated with decreased levels of CXCL10, suggesting that this chemokine exerts tumor-suppressor properties in myeloma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCL10 antibody

Reference Product	PubMed Publications
CXCL9 antibody	>898 publications with CXCL10 and CXCL9
CXCR3 antibody	>817 publications with CXCL10 and CXCR3
CCL5 antibody	>637 publications with CXCL10 and CCL5
CXCL11 antibody	>455 publications with CXCL10 and CXCL11
CCR5 antibody	>170 publications with CXCL10 and CCR5
CCL20 antibody	>107 publications with CXCL10 and CCL20
CCL11 antibody	>99 publications with CXCL10 and CCL11
CXCR2 antibody	>50 publications with CXCL10 and CXCR2
CCR3 antibody	>47 publications with CXCL10 and CCR3
CCR1 antibody	>46 publications with CXCL10 and CCR1

Pathways associated with anti-CXCL10 antibody

Products by Pathway	Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram

Diseases associated with anti-CXCL10 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>1136 publications with CXCL10 and Inflammation
Necrosis Antibodies	>658 publications with CXCL10 and Necrosis
Lung Diseases Antibodies	>327 publications with CXCL10 and Lung Diseases
Liver Diseases Antibodies	>226 publications with CXCL10 and Liver Diseases
Cardiovascular Diseases Antibodies	>167 publications with CXCL10 and Cardiovascular Diseases
Fibrosis Antibodies	>125 publications with CXCL10 and Fibrosis
Neoplasms, Experimental Antibodies	>111 publications with CXCL10 and Neoplasms, Experimental
Kidney Diseases Antibodies	>85 publications with CXCL10 and Kidney Diseases
Lung Injury Antibodies	>63 publications with CXCL10 and Lung Injury
Pneumonia Antibodies	>59 publications with CXCL10 and Pneumonia

Organs/Tissues associated with anti-CXCL10 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1986 publications with CXCL10 and Blood
Lung Antibodies	>443 publications with CXCL10 and Lung
Liver Antibodies	>262 publications with CXCL10 and Liver
Kidney Antibodies	>175 publications with CXCL10 and Kidney
Lymph Node Antibodies	>157 publications with CXCL10 and Lymph Node
Muscle Antibodies	>118 publications with CXCL10 and Muscle
Intestine Antibodies	>87 publications with CXCL10 and Intestine
Nerve Antibodies	>60 publications with CXCL10 and Nerve
Uterus Antibodies	>33 publications with CXCL10 and Uterus
Placenta Antibodies	>27 publications with CXCL10 and Placenta