HCK Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: Oncoprotein; EC 2.7.10.2; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Src family

Chromosomal Location of Human Ortholog: 20q11-q12

Cellular Component: Golgi apparatus; transport vesicle; extrinsic to internal side of plasma membrane; cell projection; focal adhesion; lysosome; actin filament; caveola; nucleus; cytosol

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: integrin-mediated signaling pathway; respiratory burst after phagocytosis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; regulation of phagocytosis; protein amino acid phosphorylation; regulation of defense response to virus by virus; regulation of cell shape; leukocyte migration during immune response; positive regulation of actin filament polymerization; regulation of transcription factor activity; leukocyte degranulation; positive regulation of cell proliferation; regulation of inflammatory response; lipopolysaccharide-mediated signaling pathway; innate immune response; mesoderm development; cell differentiation; inflammatory response; innate immune response-activating signal transduction; cell adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis