Rabbit Anti-TNFRSF14 Polyclonal Antibody – Cat# MBS126992

Western blot analysis of extracts of Raji cells, using TNFRSF14 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.

TNFRSF14 Antibody – Rabbit Polyclonal

Name: TNFRSF14 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS126992
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS126992

The mammalian tumor necrosis factor receptor (TNFR) family consists of 10 cell-surface proteins that regulate development and homeostasis of the immune system. Member 14 of TNFR (TNFRSF14, also named as TR2, ATAR, HVEA, HVEM, LIGHTR) was also identified as a… More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TNFRSF14, Polyclonal Antibody

Full Product Name

TNFRSF14 Polyclonal Antibody

Product Gene Name

anti-TNFRSF14 antibody

Product Synonym Names

ATAR; HVEA; HVEM; LIGHTR; TR2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

283

OMIM

602746

3D Structure

ModBase 3D Structure for Q92956

Species

Human

Immunogen

Recombinant protein of human TNFRSF14

Calculated Molecular Weight

30kDa

Product Categories/Family for anti-TNFRSF14 antibody

Polyclonal

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-TNFRSF14 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-TNFRSF14 antibody

WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Other Notes

Small volumes of anti-TNFRSF14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF14 purchase

MBS126992 is an antibody targeting TNFRSF14. Also known as TNFRSF14 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF14. It may not necessarily be applicable to this product.

NCBI GI #

13878821

NCBI GeneID

8764

NCBI Accession #

Q92956.3

UniProt Primary Accession #

Q92956

UniProt Secondary Accession #

Q6IB95; Q8N634; Q8WXR1; Q96J31; Q9UM65; B3KW30; B9DI89

UniProt Related Accession #

Q92956

NCBI Official Full Name

Tumor necrosis factor receptor superfamily member 14

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 14

NCBI Official Symbol

TNFRSF14

NCBI Official Synonym Symbols

TR2; ATAR; HVEA; HVEM; CD270; LIGHTR

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 14

UniProt Synonym Protein Names

Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD_antigen: CD270

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

TNFRSF14

UniProt Synonym Gene Names

HVEA; HVEM; Herpesvirus entry mediator A; HveA; TR2

UniProt Entry Name

TNR14_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 14; CD40-like protein; herpes virus entry mediator A; tumor necrosis factor receptor-like gene2; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

NCBI Summary for TNFRSF14

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

UniProt Comments for TNFRSF14

TNFRSF14: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

Protein type: Receptor, misc.; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p36.32

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: viral receptor activity; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; entry of virus into host cell; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; T cell costimulation; positive regulation of cytokine secretion during immune response; negative regulation of alpha-beta T cell proliferation; immune response; defense response to Gram-negative bacterium

Research Articles on TNFRSF14

1. Relative expression of HVEM and LTbetaR modulates canonical NF-kappaB and pro-apoptotic signals stimulated by LIGHT.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFRSF14 antibody

Reference Product	PubMed Publications
BTLA antibody	>71 publications with TNFRSF14 and BTLA
TNFSF14 antibody	>67 publications with TNFRSF14 and TNFSF14
TRAF2 antibody	>5 publications with TNFRSF14 and TRAF2

Pathways associated with anti-TNFRSF14 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram

Diseases associated with anti-TNFRSF14 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>280 publications with TNFRSF14 and Necrosis
Inflammation Antibodies	>38 publications with TNFRSF14 and Inflammation
Arthritis, Rheumatoid Antibodies	>20 publications with TNFRSF14 and Arthritis, Rheumatoid
Carcinoma Antibodies	>9 publications with TNFRSF14 and Carcinoma
Nervous System Diseases Antibodies	>9 publications with TNFRSF14 and Nervous System Diseases
Liver Diseases Antibodies	>8 publications with TNFRSF14 and Liver Diseases
Neoplasms, Experimental Antibodies	>6 publications with TNFRSF14 and Neoplasms, Experimental
Anemia Antibodies	>5 publications with TNFRSF14 and Anemia
Carcinoma, Hepatocellular Antibodies	>2 publications with TNFRSF14 and Carcinoma, Hepatocellular
Anemia, Hemolytic Antibodies	>2 publications with TNFRSF14 and Anemia, Hemolytic

Organs/Tissues associated with anti-TNFRSF14 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>145 publications with TNFRSF14 and Blood
Bone Antibodies	>14 publications with TNFRSF14 and Bone
Liver Antibodies	>11 publications with TNFRSF14 and Liver
Intestine Antibodies	>11 publications with TNFRSF14 and Intestine
Eye Antibodies	>11 publications with TNFRSF14 and Eye
Spleen Antibodies	>10 publications with TNFRSF14 and Spleen
Lymph Node Antibodies	>10 publications with TNFRSF14 and Lymph Node
Lymph Antibodies	>9 publications with TNFRSF14 and Lymph
Muscle Antibodies	>7 publications with TNFRSF14 and Muscle
Ovary Antibodies	>7 publications with TNFRSF14 and Ovary