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UGDH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS127126
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UDP-GlcDH (also called UDP-glucose 6-dehydrogenase, UGDH or UDPGDH) is a member of the UDP-glucose/GDP-mannose dehydrogenase family. UDP-GlcDH converts UDP-glucose to UDP-glucuronic acid, which is a crucial component in the biosynthesis of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
UGDH, Polyclonal Antibody
Full Product Name
UGDH Polyclonal Antibody
Product Gene Name
anti-UGDH antibody
Product Synonym Names
UGDH; GDH; UDP-GlcDH; UDPGDH; UGD
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
494
OMIM
603370
3D Structure
ModBase 3D Structure for O60701
Species
Human
Immunogen
Recombinant protein of human UGDH
Calculated Molecular Weight
55kDa

Product Categories/Family for anti-UGDH antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-UGDH antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-UGDH antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Western Blot (WB) of anti-UGDH antibody

Western blot analysis of extracts of various cell lines, using UGDH Antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Rabbit Anti-UGDH Polyclonal Antibody – Cat# MBS127126

Immunohistochemistry (IHC) of anti-UGDH antibody

Immunohistochemistry of paraffin-embedded rat brain using UGDH antibody at dilution of 1:100 (40x lens).
Rabbit Anti-UGDH Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS127126

Immunohistochemistry (IHC) of anti-UGDH antibody

Immunohistochemistry of paraffin-embedded human liver cancer using UGDH antibody at dilution of 1:100 (40x lens).
Rabbit Anti-UGDH Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS127126

Immunofluorescence (IF) of anti-UGDH antibody

Immunofluorescence analysis of HeLa cells using UGDH antibody. Blue: DAPI for nuclear staining.
Rabbit Anti-UGDH Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS127126

Other Notes

Small volumes of anti-UGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UGDH purchase

MBS127126 is an antibody targeting UGDH. Also known as UGDH Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UGDH. It may not necessarily be applicable to this product.

NCBI GI #
6175086
NCBI GeneID
7358
NCBI Accession #
O60701.1
UniProt Primary Accession #
O60701
UniProt Secondary Accession #
O60589; B3KUU2; B4DN25
UniProt Related Accession #
O60701
NCBI Official Full Name
UDP-glucose 6-dehydrogenase
NCBI Official Synonym Full Names
UDP-glucose 6-dehydrogenase
NCBI Official Symbol
UGDH
NCBI Official Synonym Symbols
GDH; UGD; UDPGDH; UDP-GlcDH
UniProt Protein Name
UDP-glucose 6-dehydrogenase
UniProt Gene Name
UGDH
UniProt Synonym Gene Names
UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH
UniProt Entry Name
UGDH_HUMAN
NCBI Protein Information
UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UDP-glucose dehydrogenase; uridine diphospho-glucose dehydrogenase

NCBI Summary for UGDH

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for UGDH

UGDH: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Motility/polarity/chemotaxis; Carbohydrate Metabolism - starch and sucrose; EC 1.1.1.22; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - pentose and glucuronate interconversions

Chromosomal Location of Human Ortholog: 4p15.1

Cellular Component: nucleoplasm; cytosol

Molecular Function: electron carrier activity; NAD binding; UDP-glucose 6-dehydrogenase activity

Biological Process: glycosaminoglycan biosynthetic process; xenobiotic metabolic process; gastrulation with mouth forming second; UDP-glucuronate biosynthetic process; UDP-glucose metabolic process
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Research Articles on UGDH

1. Kinetic analysis of wild-type UGDH and hexamer T325A showed that upon increasing enzyme concentration, which favors the hexameric species, activity was decreased and exhibited cooperativity. Cooperative kinetics was not observed in obligate dimer T325D.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UGDH antibody

 Reference Product  PubMed Publications
 UGT1A1 antibody  >1 publications with UGDH and UGT1A1
 UGP2 antibody  >1 publications with UGDH and UGP2

Pathways associated with anti-UGDH antibody

 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies  Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
 Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies  Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
 Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies  Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
 Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies  Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram
 Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway antibodies  Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway Diagram

Diseases associated with anti-UGDH antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4 publications with UGDH and Cardiovascular Diseases
 Heart Diseases Antibodies  >3 publications with UGDH and Heart Diseases
 Congenital Abnormalities Antibodies  >3 publications with UGDH and Congenital Abnormalities
 Liver Diseases Antibodies  >2 publications with UGDH and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with UGDH and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >1 publications with UGDH and Neoplasm Metastasis
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with UGDH and Drug-Related Side Effects and Adverse Reactions
 Edema Antibodies  >1 publications with UGDH and Edema
 Poisoning Antibodies  >1 publications with UGDH and Poisoning
 Carcinoma, Hepatocellular Antibodies  >1 publications with UGDH and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-UGDH antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with UGDH and Liver
 Muscle Antibodies  >6 publications with UGDH and Muscle
 Prostate Antibodies  >3 publications with UGDH and Prostate
 Heart Antibodies  >3 publications with UGDH and Heart
 Bone Antibodies  >3 publications with UGDH and Bone
 Lung Antibodies  >2 publications with UGDH and Lung
 Embryonic Tissue Antibodies  >2 publications with UGDH and Embryonic Tissue
 Kidney Antibodies  >2 publications with UGDH and Kidney
 Brain Antibodies  >2 publications with UGDH and Brain
 Blood Antibodies  >1 publications with UGDH and Blood
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