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BRCA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS127140
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Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BRCA2, Polyclonal Antibody
Full Product Name
BRCA2
Product Gene Name
anti-BRCA2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human , Rat
Form/Format
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight
Observed MW: 384 kDa
Calculated MW: 384 kDa
OMIM
phenotype 613347
3D Structure
ModBase 3D Structure for P51587
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human BRCA2 (NP_000050.2)
Species Reactivity/Cross Reactivity
Human, Rat

Product Categories/Family for anti-BRCA2 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-BRCA2 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-BRCA2 antibody
WB: 1:500 - 1:2000
IF: 1:50 - 1:200

Western Blot (WB) of anti-BRCA2 antibody

Western blot analysis of extracts of 293T cells, using BRCA2 antibody (MBS127140) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-BRCA2 Polyclonal Antibody – Cat# MBS127140

Immunofluorescence (IF) of anti-BRCA2 antibody

Immunofluorescence analysis of C6 cells using BRCA2 antibody (MBS127140) at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-BRCA2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS127140

Other Notes

Small volumes of anti-BRCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BRCA2 purchase

MBS127140 is an antibody targeting BRCA2. Reactive in Human , Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BRCA2. It may not necessarily be applicable to this product.

NCBI GI #
14424438
NCBI GeneID
675
NCBI Accession #
P51587.2
UniProt Primary Accession #
P51587
UniProt Secondary Accession #
O00183; O15008; Q13879; Q5TBJ7
UniProt Related Accession #
P51587
NCBI Official Full Name
Breast cancer type 2 susceptibility protein
NCBI Official Synonym Full Names
breast cancer 2, early onset
NCBI Official Symbol
BRCA2
NCBI Official Synonym Symbols
FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2
UniProt Protein Name
Breast cancer type 2 susceptibility protein
UniProt Synonym Protein Names
Fanconi anemia group D1 protein
Protein Family
Breast cancer type 2 susceptibility protein
UniProt Gene Name
BRCA2
UniProt Synonym Gene Names
FACD; FANCD1
UniProt Entry Name
BRCA2_HUMAN
NCBI Protein Information
breast cancer type 2 susceptibility protein; Fanconi anemia group D1 protein; breast cancer 2 tumor suppressor; BRCA1/BRCA2-containing complex, subunit 2; breast and ovarian cancer susceptibility gene, early onset

UniProt Comments for BRCA2

BRCA2: involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation. Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoint functions. Interacts with WDR16. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer and may underlie susceptibility to uveal melanoma.

Protein type: Tumor suppressor; Nuclear receptor co-regulator; DNA repair, damage

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; centrosome; protein complex; cytoplasm; BRCA2-MAGE-D1 complex; nucleus; secretory granule

Molecular Function: gamma-tubulin binding; protein binding; H4 histone acetyltransferase activity; histone acetyltransferase activity; protease binding; H3 histone acetyltransferase activity; single-stranded DNA binding

Biological Process: positive regulation of transcription, DNA-dependent; cytokinesis; cell aging; positive regulation of mitotic cell cycle; DNA repair; regulation of cytokinesis; oocyte maturation; inner cell mass cell proliferation; negative regulation of mammary gland epithelial cell proliferation; response to UV-C; double-strand break repair via homologous recombination; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; male meiosis I; nucleotide-excision repair; double-strand break repair; response to gamma radiation; hemopoiesis; spermatogenesis; replication fork protection; brain development; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; centrosome duplication; female gonad development; response to X-ray

Disease: Pancreatic Cancer, Susceptibility To, 2; Breast-ovarian Cancer, Familial, Susceptibility To, 2; Prostate Cancer; Breast Cancer; Medulloblastoma; Glioma Susceptibility 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Fanconi Anemia, Complementation Group D1; Wilms Tumor 1
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Research Articles on BRCA2

1. Findings contribute significantly to the types of germline BRCA1/BRCA2 mutations and their biological effects in Turkish women.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BRCA2 antibody

 Reference Product  PubMed Publications
 BRCA1 antibody  >5661 publications with BRCA2 and BRCA1
 RAD51 antibody  >470 publications with BRCA2 and RAD51
 TP53 antibody  >278 publications with BRCA2 and TP53
 ATM antibody  >271 publications with BRCA2 and ATM
 PALB2 antibody  >202 publications with BRCA2 and PALB2
 FANCD2 antibody  >119 publications with BRCA2 and FANCD2
 XRCC3 antibody  >49 publications with BRCA2 and XRCC3
 FANCG antibody  >31 publications with BRCA2 and FANCG
 SHFM1 antibody  >19 publications with BRCA2 and SHFM1
 HMG20B antibody  >8 publications with BRCA2 and HMG20B

Pathways associated with anti-BRCA2 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Homologous DNA Pairing And Strand Exchange Pathway antibodies  Homologous DNA Pairing And Strand Exchange Pathway Diagram
 Homologous Recombination Repair Pathway antibodies  Homologous Recombination Repair Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram

Diseases associated with anti-BRCA2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4748 publications with BRCA2 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >2665 publications with BRCA2 and Ovarian Neoplasms
 Adenocarcinoma Antibodies  >455 publications with BRCA2 and Adenocarcinoma
 Anemia Antibodies  >286 publications with BRCA2 and Anemia
 Fanconi Anemia Antibodies  >274 publications with BRCA2 and Fanconi Anemia
 Neoplasms, Experimental Antibodies  >242 publications with BRCA2 and Neoplasms, Experimental
 Pancreatic Neoplasms Antibodies  >235 publications with BRCA2 and Pancreatic Neoplasms
 Hereditary Breast and Ovarian Cancer Syndrome Antibodies  >228 publications with BRCA2 and Hereditary Breast and Ovarian Cancer Syndrome
 Prostatic Neoplasms Antibodies  >178 publications with BRCA2 and Prostatic Neoplasms
 Neoplasm Metastasis Antibodies  >112 publications with BRCA2 and Neoplasm Metastasis

Organs/Tissues associated with anti-BRCA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >111 publications with BRCA2 and Lymph Node
 Lung Antibodies  >84 publications with BRCA2 and Lung
 Pancreas Antibodies  >70 publications with BRCA2 and Pancreas
 Mammary Gland Antibodies  >67 publications with BRCA2 and Mammary Gland
 Brain Antibodies  >57 publications with BRCA2 and Brain
 Bone Marrow Antibodies  >56 publications with BRCA2 and Bone Marrow
 Liver Antibodies  >45 publications with BRCA2 and Liver
 Vascular Antibodies  >33 publications with BRCA2 and Vascular
 Kidney Antibodies  >26 publications with BRCA2 and Kidney
 Testis Antibodies  >24 publications with BRCA2 and Testis
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