PTGS2 Antibody – Rabbit Polyclonal

humans, catalyze prostaglandin production from arachidonic acid (1,2). While Cox1 expression is constitutive in most tissues, Cox2 expression is induced by lipopolysaccharide (LPS) and peptidoglycan (PGN) (3). PGN activates Ras, leading to phosphorylation of Raf at Ser338 and Erk1/2 at Tyr204. The activation of MAP kinase signaling results in subsequent activation of IKKalpha/beta, phosphorylation of IkappaBalpha at Ser32/36, and NFkappaB activation. Finally, activation of the transcription factor NFkappaB is responsible for the induction of Cox2 expression (4). Investigators have shown that LPS and PGN induce the clinical manifestations of arthritis and bacterial infections, such as inflammation, fever, and septic shock (5). Research studies have indicated that Cox1 and Cox2 may also play a role in the neuropathology of Alzheimer's disease by potentiating gammasecretase activity and betaamyloid generation (6).

1. Xie, W.L. et al. (1991) Proc Natl Acad Sci USA 88, 2692-6. 2. Vane, J.R. et al. (1998) Annu Rev Pharmacol Toxicol 38, 97-120. 3. O'Neill, G.P. et al. (1994) Mol Pharmacol 45, 245-54. 4. Chen, B.C. et al. (2004) J Biol Chem 279, 20889-97. 5. Wang, Q. et al. (2001) Infect Immun 69, 2270-6. 6. Qin, W. et al. (2003) J Biol Chem 278, 50970-7.

Small volumes of anti-PTGS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS127147 is an antibody targeting PTGS2. Also known as PTGS2 Polyclonal Antibody. Reactive in Human. Host: Rabbit.