Rabbit Anti-ACADM Polyclonal Antibody – Cat# MBS127291

Western blot analysis of extracts of various cell lines, using ACADM antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 1s.

ACADM Antibody – Rabbit Polyclonal

Name: ACADM Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS127291
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS127291

This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA… More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACADM, Polyclonal Antibody

Full Product Name

ACADM Polyclonal Antibody

Product Gene Name

anti-ACADM antibody

Product Synonym Names

MCAD; ACAD1; MCADH

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

421

OMIM

phenotype 607008

3D Structure

ModBase 3D Structure for P11310

Species

Human

Immunogen

Recombinant protein of human ACADM

Calculated Molecular Weight

46kDa

Product Categories/Family for anti-ACADM antibody

Polyclonal

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-ACADM antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-ACADM antibody

WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Other Notes

Small volumes of anti-ACADM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACADM purchase

MBS127291 is an antibody targeting ACADM. Also known as ACADM Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACADM. It may not necessarily be applicable to this product.

NCBI GI #

113017

NCBI GeneID

NCBI Accession #

P11310.1

UniProt Primary Accession #

P11310

UniProt Secondary Accession #

Q5T4U4; Q9NYF1

UniProt Related Accession #

P11310

NCBI Official Full Name

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

NCBI Official Synonym Full Names

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

NCBI Official Symbol

ACADM

NCBI Official Synonym Symbols

MCAD; ACAD1; MCADH

UniProt Protein Name

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Protein Family

Medium-chain specific acyl-CoA dehydrogenase

UniProt Gene Name

ACADM

UniProt Synonym Gene Names

MCAD

UniProt Entry Name

ACADM_HUMAN

NCBI Protein Information

medium-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain

UniProt Comments for ACADM

ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.3.8.7; Mitochondrial; Carbohydrate Metabolism - propanoate; Oxidoreductase; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: mitochondrion; axon; mitochondrial matrix; nucleus

Molecular Function: acyl-CoA dehydrogenase activity; identical protein binding; FAD binding

Biological Process: carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; medium-chain fatty acid catabolic process; cellular lipid metabolic process; medium-chain fatty acid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; carnitine biosynthetic process

Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of

Research Articles on ACADM

1. mutations in the ACADM gene lower the temperature threshold at which medium-chain acyl-CoA dehydrogenase deficiency loss-of-function occurs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ACADM antibody

Reference Product	PubMed Publications
ACADL antibody	>7 publications with ACADM and ACADL
CPT1A antibody	>3 publications with ACADM and CPT1A
ECHS1 antibody	>1 publications with ACADM and ECHS1
EHHADH antibody	>1 publications with ACADM and EHHADH
ACAA2 antibody	>1 publications with ACADM and ACAA2
HADHB antibody	>1 publications with ACADM and HADHB

Pathways associated with anti-ACADM antibody

Products by Pathway	Pathway Diagram
Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway antibodies	Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway Diagram
Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway antibodies	Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies	FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
Fatty Acid Beta Oxidation Pathway antibodies	Fatty Acid Beta Oxidation Pathway Diagram
Fatty Acid Degradation Pathway antibodies	Fatty Acid Degradation Pathway Diagram
Fatty Acid Degradation Pathway antibodies	Fatty Acid Degradation Pathway Diagram
Fatty Acid Metabolism Pathway antibodies	Fatty Acid Metabolism Pathway Diagram
Fatty Acid Metabolism Pathway antibodies	Fatty Acid Metabolism Pathway Diagram

Diseases associated with anti-ACADM antibody

Disease Name	Pubmed Publications
Medium chain acyl CoA dehydrogenase deficiency Antibodies	>20 publications with ACADM and Medium chain acyl CoA dehydrogenase deficiency
Fatty Liver Antibodies	>12 publications with ACADM and Fatty Liver
Obesity Antibodies	>5 publications with ACADM and Obesity
Liver Diseases Antibodies	>4 publications with ACADM and Liver Diseases
Cardiovascular Diseases Antibodies	>4 publications with ACADM and Cardiovascular Diseases
Hepatomegaly Antibodies	>3 publications with ACADM and Hepatomegaly
Heart Diseases Antibodies	>3 publications with ACADM and Heart Diseases
Inflammation Antibodies	>2 publications with ACADM and Inflammation
Insulin Resistance Antibodies	>2 publications with ACADM and Insulin Resistance
Disease Models, Animal Antibodies	>2 publications with ACADM and Disease Models, Animal

Organs/Tissues associated with anti-ACADM antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>18 publications with ACADM and Blood
Liver Antibodies	>13 publications with ACADM and Liver
Muscle Antibodies	>5 publications with ACADM and Muscle
Heart Antibodies	>5 publications with ACADM and Heart
Adipose Tissue Antibodies	>5 publications with ACADM and Adipose Tissue
Connective Tissue Antibodies	>3 publications with ACADM and Connective Tissue
Kidney Antibodies	>3 publications with ACADM and Kidney
Thyroid Antibodies	>2 publications with ACADM and Thyroid
Vascular Antibodies	>2 publications with ACADM and Vascular
Pancreas Antibodies	>2 publications with ACADM and Pancreas