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PTPN11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS127309
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic… More details

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Product Overview

Online Datasheet in PDF
Product Name
PTPN11, Polyclonal Antibody
Full Product Name
PTPN11 Polyclonal Antibody
Product Gene Name
anti-PTPN11 antibody
Product Synonym Names
CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
593
OMIM
gene 607785
3D Structure
ModBase 3D Structure for Q06124
Species
Human
Immunogen
Fusion protein of human PTPN11
Calculated Molecular Weight
68kDa

Product Categories/Family for anti-PTPN11 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PTPN11 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PTPN11 antibody
WB: 1:500 - 1:1000
IHC: 1:50 - 1:100

Western Blot (WB) of anti-PTPN11 antibody

Western blot analysis of extracts of various cell lines, using PTPN11 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-PTPN11 Polyclonal Antibody – Cat# MBS127309

Immunohistochemistry (IHC) of anti-PTPN11 antibody

Immunohistochemistry of paraffin-embedded rat spleen using PTPN11 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-PTPN11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS127309

Immunohistochemistry (IHC) of anti-PTPN11 antibody

Immunohistochemistry of paraffin-embedded rat heart using PTPN11 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-PTPN11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS127309

Immunohistochemistry (IHC) of anti-PTPN11 antibody

Immunohistochemistry of paraffin-embedded human esophagus using PTPN11 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-PTPN11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS127309

Immunohistochemistry (IHC) of anti-PTPN11 antibody

Immunohistochemistry of paraffin-embedded human gastric cancer using PTPN11 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-PTPN11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS127309

Immunohistochemistry (IHC) of anti-PTPN11 antibody

Immunohistochemistry of paraffin-embedded mouse spleen using PTPN11 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-PTPN11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS127309

Other Notes

Small volumes of anti-PTPN11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTPN11 purchase

MBS127309 is an antibody targeting PTPN11. Also known as PTPN11 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPN11. It may not necessarily be applicable to this product.

NCBI GI #
84028248
NCBI GeneID
5781
NCBI Accession #
Q06124.2
UniProt Primary Accession #
Q06124
UniProt Secondary Accession #
Q96HD7; A8K1D9
UniProt Related Accession #
Q06124
NCBI Official Full Name
Tyrosine-protein phosphatase non-receptor type 11
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 11
NCBI Official Symbol
PTPN11
NCBI Official Synonym Symbols
CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 11
UniProt Synonym Protein Names
Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3
Protein Family
Tyrosine-protein phosphatase non-receptor
UniProt Gene Name
PTPN11
UniProt Synonym Gene Names
PTP2C; SHPTP2; PTP-1D; PTP-2C; SHP-2; Shp2
UniProt Entry Name
PTN11_HUMAN
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 11; PTP-2C; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C

UniProt Comments for PTPN11

SHP-2: a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: protein complex; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: protein domain specific binding; protein binding; phospholipase binding; peptide hormone receptor binding; SH3/SH2 adaptor activity; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; D1 dopamine receptor binding; phosphoprotein phosphatase activity; insulin receptor binding

Biological Process: axon guidance; hormone-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPK activity; heart development; platelet-derived growth factor receptor signaling pathway; positive regulation of mitotic cell cycle; reproductive process in a multicellular organism; glucose homeostasis; regulation of protein export from nucleus; negative regulation of insulin secretion; regulation of cell adhesion mediated by integrin; ephrin receptor signaling pathway; abortive mitotic cell cycle; negative regulation of cell adhesion mediated by integrin; inner ear development; integrin-mediated signaling pathway; negative regulation of growth hormone secretion; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cytokine and chemokine mediated signaling pathway; positive regulation of hormone secretion; regulation of multicellular organism growth; negative regulation of cortisol secretion; organ growth; genitalia development; triacylglycerol metabolic process; T cell costimulation; DNA damage checkpoint; insulin receptor signaling pathway; innate immune response; hormone metabolic process; brain development; platelet formation; blood coagulation; leukocyte migration

Disease: Metachondromatosis; Noonan Syndrome 1; Juvenile Myelomonocytic Leukemia; Leopard Syndrome 1
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Research Articles on PTPN11

1. This finding not only provides an alternative mechanism for how CagA and ROS coregulate SHP2 activation but may also explain their roles in H. pylori-induced IFN-gamma resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTPN11 antibody

 Reference Product  PubMed Publications
 GRB2 antibody  >170 publications with PTPN11 and GRB2
 JAK2 antibody  >102 publications with PTPN11 and JAK2
 GAB1 antibody  >90 publications with PTPN11 and GAB1
 GAB2 antibody  >50 publications with PTPN11 and GAB2
 EGFR antibody  >45 publications with PTPN11 and EGFR
 IRS1 antibody  >42 publications with PTPN11 and IRS1
 PDGFRB antibody  >32 publications with PTPN11 and PDGFRB
 IGF1R antibody  >19 publications with PTPN11 and IGF1R
 FRS2 antibody  >14 publications with PTPN11 and FRS2

Pathways associated with anti-PTPN11 antibody

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram

Diseases associated with anti-PTPN11 antibody

 Disease Name  Pubmed Publications
 Noonan Syndrome Antibodies  >374 publications with PTPN11 and Noonan Syndrome
 Heart Diseases Antibodies  >361 publications with PTPN11 and Heart Diseases
 Leukemia Antibodies  >277 publications with PTPN11 and Leukemia
 LEOPARD Syndrome Antibodies  >129 publications with PTPN11 and LEOPARD Syndrome
 Leukemia, Myelomonocytic, Juvenile Antibodies  >94 publications with PTPN11 and Leukemia, Myelomonocytic, Juvenile
 Carcinoma Antibodies  >84 publications with PTPN11 and Carcinoma
 Inflammation Antibodies  >65 publications with PTPN11 and Inflammation
 Costello Syndrome Antibodies  >46 publications with PTPN11 and Costello Syndrome
 Adenocarcinoma Antibodies  >42 publications with PTPN11 and Adenocarcinoma
 Disease Models, Animal Antibodies  >39 publications with PTPN11 and Disease Models, Animal

Organs/Tissues associated with anti-PTPN11 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >424 publications with PTPN11 and Blood
 Heart Antibodies  >187 publications with PTPN11 and Heart
 Bone Antibodies  >131 publications with PTPN11 and Bone
 Muscle Antibodies  >115 publications with PTPN11 and Muscle
 Bone Marrow Antibodies  >101 publications with PTPN11 and Bone Marrow
 Brain Antibodies  >100 publications with PTPN11 and Brain
 Liver Antibodies  >65 publications with PTPN11 and Liver
 Skin Antibodies  >57 publications with PTPN11 and Skin
 Nerve Antibodies  >55 publications with PTPN11 and Nerve
 Stomach Antibodies  >53 publications with PTPN11 and Stomach
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