RAP2A Antibody – Rabbit Polyclonal

RAP2A: Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. Belongs to the small GTPase superfamily. Ras family.

Protein type: G protein, monomeric; G protein; G protein, monomeric, Ras

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: recycling endosome; recycling endosome membrane; plasma membrane; midbody; cytosol

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: microvillus biogenesis; establishment of protein localization; metabolic process; regulation of dendrite morphogenesis; actin cytoskeleton reorganization; establishment of epithelial cell polarity; positive regulation of protein amino acid phosphorylation; positive regulation of protein amino acid autophosphorylation; negative regulation of cell migration; regulation of JNK cascade; Rap protein signal transduction