Rabbit Anti-SMC5 Polyclonal Antibody – Cat# MBS127738

Western blot analysis of extracts of various cell lines, using SMC5 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.

SMC5 Antibody – Rabbit Polyclonal

Name: SMC5 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS127738
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS127738

MBS127738 is an antibody targeting SMC5. Also known as SMC5 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SMC5, Polyclonal Antibody

Full Product Name

SMC5 Polyclonal Antibody

Product Gene Name

anti-SMC5 antibody

Product Synonym Names

SMC5L1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

1101

OMIM

609386

3D Structure

ModBase 3D Structure for Q8IY18

Species

Human

Immunogen

Recombinant protein of human SMC5

Calculated Molecular Weight

129kDa

Product Categories/Family for anti-SMC5 antibody

Polyclonal

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-SMC5 antibody

Western Blot (WB)

Application Notes for anti-SMC5 antibody

WB: 1:500 - 1:2000

Other Notes

Small volumes of anti-SMC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SMC5. It may not necessarily be applicable to this product.

NCBI GI #

122070387

NCBI GeneID

23137

NCBI Accession #

Q8IY18.2

UniProt Primary Accession #

Q8IY18

UniProt Secondary Accession #

O60335; Q05D92; Q5VZ60; Q96SB9; A6NM81

UniProt Related Accession #

Q8IY18

NCBI Official Full Name

Structural maintenance of chromosomes protein 5

NCBI Official Synonym Full Names

structural maintenance of chromosomes 5

NCBI Official Symbol

SMC5

NCBI Official Synonym Symbols

SMC5L1

UniProt Protein Name

Structural maintenance of chromosomes protein 5

Protein Family

Structural maintenance of chromosomes protein

UniProt Gene Name

SMC5

UniProt Synonym Gene Names

KIAA0594; SMC5L1; SMC protein 5; SMC-5; hSMC5

UniProt Entry Name

SMC5_HUMAN

NCBI Protein Information

structural maintenance of chromosomes protein 5; SMC-5; hSMC5; SMC protein 5; SMC5 structural maintenance of chromosomes 5-like 1

UniProt Comments for SMC5

SMC5: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. Belongs to the SMC family. SMC5 subfamily.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 9q21.12

Cellular Component: nucleoplasm; PML body; chromosome, telomeric region; cell junction; nucleus

Molecular Function: protein binding; ATP binding

Biological Process: mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; cell division; telomere maintenance via recombination; positive regulation of mitotic metaphase/anaphase transition; double-strand break repair via nonhomologous end joining; double-strand break repair via homologous recombination

Research Articles on SMC5

1. Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SMC5 antibody

Reference Product	PubMed Publications
SMC6 antibody	>104 publications with SMC5 and SMC6
RAD52 antibody	>8 publications with SMC5 and RAD52
NSMCE2 antibody	>8 publications with SMC5 and NSMCE2
NDNL2 antibody	>2 publications with SMC5 and NDNL2
FANCM antibody	>1 publications with SMC5 and FANCM

Diseases associated with anti-SMC5 antibody

Disease Name	Pubmed Publications
Abnormalities, Drug-Induced Antibodies	>2 publications with SMC5 and Abnormalities, Drug-Induced
Abnormalities, Multiple Antibodies	>2 publications with SMC5 and Abnormalities, Multiple
Congenital Abnormalities Antibodies	>2 publications with SMC5 and Congenital Abnormalities
Precancerous Conditions Antibodies	>1 publications with SMC5 and Precancerous Conditions
Ataxia Antibodies	>1 publications with SMC5 and Ataxia
Cleft Palate Antibodies	>1 publications with SMC5 and Cleft Palate
Nervous System Diseases Antibodies	>1 publications with SMC5 and Nervous System Diseases

Organs/Tissues associated with anti-SMC5 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>3 publications with SMC5 and Testis
Muscle Antibodies	>1 publications with SMC5 and Muscle
Eye Antibodies	>1 publications with SMC5 and Eye
Brain Antibodies	>1 publications with SMC5 and Brain